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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sclt1Tg(CAG-sb10)1Dla
transgene insertion 1, David A Largaespada
MGI:3612989
Summary 5 genotypes


Genotype
MGI:6110829
hm1
Allelic
Composition		 Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic
Background		 FVB/N-Sclt1Tg(CAG-sb10)1Dla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sclt1Tg(CAG-sb10)1Dla mutation (1 available); any Sclt1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney morphology ( J:243427 )
• paler kidneys by P8
kidney medulla cyst ( J:243427 )
• cysts originate from both collecting and proximal tubule
polycystic kidney ( J:243427 )
• decreased cellularity in cyst-lining epithelium by P21
enlarged kidney ( J:243427 )
• moderately larger kidneys by P8
• 3-fold larger kidneys by P21

growth/size/body
growth/size/body region phenotype ( J:243427 )
N
• body weight
cleft palate ( J:243427 )
• increased frequency
slow postnatal weight gain ( J:243427 )
• growth retardation by P8
cachexia ( J:243427 )
kidney medulla cyst ( J:243427 )
• cysts originate from both collecting and proximal tubule
polycystic kidney ( J:243427 )
• decreased cellularity in cyst-lining epithelium by P21
enlarged kidney ( J:243427 )
• moderately larger kidneys by P8
• 3-fold larger kidneys by P21

digestive/alimentary system
cleft palate ( J:243427 )
• increased frequency

homeostasis/metabolism

limbs/digits/tail
preaxial polydactyly ( J:243427 )
• in hind limbs

mortality/aging
premature death ( J:243427 )
• pups die before age 1 month

craniofacial
cleft palate ( J:243427 )
• increased frequency




Genotype
MGI:3613026
cx2
Allelic
Composition		 Sclt1Tg(CAG-sb10)1Dla/0
TgTn(sb-T2/Onc)68Dla/0
Genetic
Background		 FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1Tg(CAG-sb10)1Dla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sclt1Tg(CAG-sb10)1Dla mutation (1 available); any Sclt1 mutation (39 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:99991 )
N
• up to 1 year of age no signs of increased tumor susceptibility are seen




Genotype
MGI:3613025
cx3
Allelic
Composition		 Sclt1Tg(CAG-sb10)1Dla/0
TgTn(sb-T2/Onc)76Dla/0
Genetic
Background		 FVB/N-TgTn(sb-T2/Onc)76Dla Sclt1Tg(CAG-sb10)1Dla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sclt1Tg(CAG-sb10)1Dla mutation (1 available); any Sclt1 mutation (39 available)
TgTn(sb-T2/Onc)76Dla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:99991 )
N
• up to 1 year of age no signs of increased tumor susceptibility are seen




Genotype
MGI:3613023
cx4
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Sclt1Tg(CAG-sb10)1Dla/0
TgTn(sb-T2/Onc)76Dla/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Sclt1Tg(CAG-sb10)1Dla mutation (1 available); any Sclt1 mutation (39 available)
TgTn(sb-T2/Onc)76Dla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99991 )
• mice died earlier than those homozygous for Cdkn2atm1Cjs alone

neoplasm
increased tumor incidence ( J:99991 )
• tumor spectrum was similar to Cdkn2atm1Cjs homozygotes and included malignant meningiomas
increased leukemia incidence ( J:99991 )
• myeloid leukemias were seen
increased lung adenocarcinoma incidence ( J:99991 )
• a pulmonary adenocarcinoma was seen
increased sarcoma incidence ( J:99991 )
• soft tissue sarcomas or osteosarcomas

respiratory system
increased lung adenocarcinoma incidence ( J:99991 )
• a pulmonary adenocarcinoma was seen

skeleton




Genotype
MGI:3613024
cx5
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Sclt1Tg(CAG-sb10)1Dla/0
TgTn(sb-T2/Onc)68Dla/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Sclt1Tg(CAG-sb10)1Dla mutation (1 available); any Sclt1 mutation (39 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99991 )
• mice died earlier than those homozygous for Cdkn2atm1Cjs alone

neoplasm
increased tumor incidence ( J:99991 )
• tumor spectrum was similar to Cdkn2atm1Cjs homozygotes and included malignant meningiomas
increased leukemia incidence ( J:99991 )
• myeloid leukemias were seen
increased lung adenocarcinoma incidence ( J:99991 )
• a pulmonary adenocarcinoma was seen
increased sarcoma incidence ( J:99991 )
• soft tissue sarcomas or osteosarcomas

respiratory system
increased lung adenocarcinoma incidence ( J:99991 )
• a pulmonary adenocarcinoma was seen

skeleton




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory