Phenotypes associated with this allele

• Allele Symbol: Tg(gptdelta)1Nmi
• Allele Name: transgene insertion 1, Takehito Nohmi
• Allele ID: MGI:3612991
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ogg1^tm1Tno/Ogg1^tm1Tno Tg(gptdelta)1Nmi/0	involves: 129S4/SvJae * C57BL/6J	MGI:3783754
cx2	Poli^tm1.1Lgh/Poli^tm1.1Lgh Tg(gptdelta)1Nmi/0	involves: C57BL/6J	MGI:5582780

Genotype
MGI:3783754

cx1

• Allelic Composition: Ogg1^tm1Tno/Ogg1^tm1Tno; Tg(gptdelta)1Nmi/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:61684 , J:84649 )

• liver DNA from double mutants exhibits more than a 2-fold elevation in spontaneous mutations (single base substitutions) compared to Ogg1-sufficient gpt hemizygotes (J:61684)

• mutation frequency is higher than in Ogg1-wild-type transgenic animals; frequency tends to increase after liver regeneration following partial hepatectomy (J:84649)

• spectrum of mutations in cultured mutant liver cells shows an increase in number transverions (GC->AT) and number of deletion mutations is increased during liver regeneration (J:84649)

Genotype
MGI:5582780

cx2

• Allelic Composition: Poli^tm1.1Lgh/Poli^tm1.1Lgh; Tg(gptdelta)1Nmi/0
• Genetic Background: involves: C57BL/6J

neoplasm

neoplasm ( J:212610 )

♂N • mice exhibit normal spontaneous tumor rates

increased incidence of tumors by chemical induction ( J:212610 )

♂ • 1.8 times greater than in Tg(gptdelta)1Nmi mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:212610 )

♂ • 1.8 times greater than in Tg(gptdelta)1Nmi mice