Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fgf8tm2Mrt targeted mutation 2, Gail R Martin MGI:3612999 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• phenotype is stated to be identical to that of Fgf8tm1.3Mrt/ Fgf8tm1.4Mrt; Nkx2-5tm1(cre)Rjs/ Nkx2-5+ mutants; however no data are presented
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• at E9.5 cell proliferation in pharyngeal endoderm is reduced with cell mitotic indices decreased by 60% relative to controls
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5
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• thinning of splanchnic mesoderm (SM) layers
• at E9.5 cell proliferation in SM is reduced with cell mitotic indices decreased by 50% relative to controls
• excessive cell death is detected from E8.5-9.5 in SM immediately distal to emerging outflow tract and in endoderm adjacent to the SM
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5, as well as in presumptive cardiac neural crest cells in close proximity to outflow tract
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• phenotype is stated to be identical to that of Fgf8tm1.3Mrt/ Fgf8tm1.4Mrt; Nkx2-5tm1(cre)Rjs/ Nkx2-5+ mutants; however no data are presented
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• anterior heart field (AHF) cells are mildly reduced compared to controls, resulting in thinning of splanchnic mesoderm (SM) layers
• at E9.5 cell proliferation in SM is reduced with cell mitotic indices decreased by 50% relative to controls; excessive cell death is detected from E8.5-9.5 in SM immediately distal to emerging outflow tract and in endoderm adjacent to the SM, with excessive cell death expanding into ventral pharyngeal endoderm by E9.5 but not in SM at this stage
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• at E9.5 cell proliferation in pharyngeal endoderm is reduced with cell mitotic indices decreased by 60% relative to controls
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5
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• indices are reduced by 50% and 60% in splanchnic mesoderm and pharyngeal endoderm at E9.5
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5, as well as in presumptive cardiac neural crest cells in close proximity to outflow tract
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cerebellar vermis aplasia present at birth
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• due to cerebellar vermis aplasia
• cerebellar hemispheres are similar in size to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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