Phenotypes associated with this allele

• Allele Symbol: Adora3^{tm1(ADORA3)Msth}
• Allele Name: targeted mutation 1, Mitsuo Satoh
• Allele ID: MGI:3613017
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adora3^tm1(ADORA3)Msth/Adora3^tm1(ADORA3)Msth	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3613463

Genotype
MGI:3613463

hm1

• Allelic Composition: Adora3^{tm1(ADORA3)Msth}/Adora3^{tm1(ADORA3)Msth}
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal mast cell physiology ( J:104494 )

• agonist-stimulated human ADORA3 did not lead to the phosphorylation of either extracellular signal-regulated kinase 1/2 or protein kinase B in BMMC isolated from mutant mice

• the rate of human ADORA3 internalization in the mast cells was also markedly decreased compared to mouse A3AR in the mutant and control mast cells, respectively

decreased mast cell degranulation ( J:104494 )

• antigen-dependent degranulation was not potentiated by an A3AR agonist in the mast cells from mutant mice

immune system

abnormal mast cell physiology ( J:104494 )

• agonist-stimulated human ADORA3 did not lead to the phosphorylation of either extracellular signal-regulated kinase 1/2 or protein kinase B in BMMC isolated from mutant mice

• the rate of human ADORA3 internalization in the mast cells was also markedly decreased compared to mouse A3AR in the mutant and control mast cells, respectively

decreased mast cell degranulation ( J:104494 )

• antigen-dependent degranulation was not potentiated by an A3AR agonist in the mast cells from mutant mice

cellular

decreased mast cell degranulation ( J:104494 )

• antigen-dependent degranulation was not potentiated by an A3AR agonist in the mast cells from mutant mice