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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dio1tm1Vag
targeted mutation 1, Valerie Anne Galton
MGI:3613031
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dio1tm1Vag/Dio1tm1Vag involves: 129 * C57BL/6 MGI:3613459


Genotype
MGI:3613459
hm1
Allelic
Composition
Dio1tm1Vag/Dio1tm1Vag
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dio1tm1Vag mutation (1 available); any Dio1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• male body weight at 6-19 weeks of age, but not at 4 weeks of age, is 5-11% greater than in wild-type

homeostasis/metabolism
• induction of hyperthyroidism by administration of a daily injection of T3 results in a greater decrease in serum cholesterol levels than in controls
• significant increase in T4 levels in the thyroids of euthyroid mice
• significant increase in T3 levels in the thyroids of euthyroid mice
• elevation in serum reverse T3 (3,3',5'-triiodothyronine) levels but not T3 (3,5,3'-triiodothyronine) or thyroid-stimulating hormone (TSH) and no evidence of peripheral hypothyroidism
• urinary excretion of [125I] iodide is markedly diminished after injection of radiolabeled T4 or T3 (for T4, 10% vs. 40% in controls; for T3, 10% vs. 45% in controls)
• induction of hyperthyroidism by administration of a daily injection of T3 results in a greater decrease in serum cholesterol levels and a larger increase in the heart weight/body weight ratio than in controls

digestive/alimentary system
• fecal excretion of endogenous iodothyronines is greatly increased, with a 2- and 3-fold increase in T4 and T3, respectively, and a 5-fold increase in rT3 and 3,3-T2
• fecal excretion of [125I] iodothyronines is greatly increased after injection of radiolabeled T4 or T3 (for T4, 70% vs. 42% in controls; for T3, 80% vs. 45% in controls)

renal/urinary system
• urinary excretion of [125I] iodide is markedly diminished after injection of radiolabeled T4 or T3 (for T4, 10% vs. 40% in controls; for T3, 10% vs. 45% in controls)

endocrine/exocrine glands
• induction of hyperthyroidism by administration of a daily injection of T3 results in a greater degree of tissue hyperthyroidism than in wild-type





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory