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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		TgTn(sb-T2/Onc2)6070Njen
transgenic transposon concatemer 6070, Nancy A Jenkins
MGI:3613048
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Aicdatm1(cre)Mnz/Aicda+
Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0 		involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J MGI:4367198
cn2
 		Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0 		involves: 129 * C57BL/6 * C57BL/6J MGI:4367197
cn3
 		Gt(ROSA)26Sortm2.1(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0 		involves: 129 * C57BL/6 * C57BL/6J MGI:4367199
cn4
 		Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0 		involves: C3H * C57BL/6 MGI:3613060


Genotype
MGI:4367198
cn1
Allelic
Composition		 Aicdatm1(cre)Mnz/Aicda+
Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Gt(ROSA)26Sortm2(sb11)Njen mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
TgTn(sb-T2/Onc2)6070Njen mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:153656 )
• compared with Gt(ROSA)26Sortm2(sb11)Njen TgTn(sb-T2/Onc2)6070Njen mice

neoplasm
increased tumor incidence ( J:153656 )
• greater than 90% of moribund mice develop tumors with an average latency of 46 weeks
increased hemolymphoid system tumor incidence ( J:153656 )
• mice develop hematopoietic tumors including B cell, T cell, and myeloid tumors unlike Gt(ROSA)26Sortm2(sb11)Njen TgTn(sb-T2/Onc2)6070Njen mice that do not develop tumors
increased T cell derived lymphoma incidence ( J:153656 )
• 3 T cell lymphomas develop
increased leukemia incidence ( J:153656 )
• 2 myeloid leukemia tumors develop
increased B cell derived lymphoma incidence ( J:153656 )
• mice develop B cell lymphomas including diffuse large cell lymphomas and follicular lymphomas
• one mouse developed pre-B lymphoma

integument

nervous system

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:153656 )
• 3 T cell lymphomas develop

immune system
increased T cell derived lymphoma incidence ( J:153656 )
• 3 T cell lymphomas develop

hematopoietic system
increased T cell derived lymphoma incidence ( J:153656 )
• 3 T cell lymphomas develop




Genotype
MGI:4367197
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(sb11)Njen mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
TgTn(sb-T2/Onc2)6070Njen mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to infection ( J:153656 )
• 2 mice develop urinary tract infections

liver/biliary system
liver cirrhosis ( J:153656 )
• in one mouse

muscle
muscle degeneration ( J:153656 )
• one mouse exhibited myocyte degeneration

integument
abnormal skin condition ( J:153656 )
• one mouse exhibited skin irritation




Genotype
MGI:4367199
cn3
Allelic
Composition		 Gt(ROSA)26Sortm2.1(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2.1(sb11)Njen mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
TgTn(sb-T2/Onc2)6070Njen mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:153656 )
• compared with Gt(ROSA)26Sortm2(sb11)Njen TgTn(sb-T2/Onc2)6070Njen and Gt(ROSA)26Sortm2(sb11)Njen Aicdatm1(cre)Mnz TgTn(sb-T2/Onc2)6070Njen mice

neoplasm
increased hemolymphoid system tumor incidence ( J:153656 )
• mice develop hematopoietic tumors including T cell and erythoid tumors
• tumor latency is 59 days
increased T cell derived lymphoma incidence ( J:153656 )
• 67% of tumors are T cell lymphomas
increased leukemia incidence ( J:153656 )
• one mouse exhibited erythroid leukemia

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:153656 )
• 67% of tumors are T cell lymphomas

hematopoietic system
increased T cell derived lymphoma incidence ( J:153656 )
• 67% of tumors are T cell lymphomas

immune system
increased T cell derived lymphoma incidence ( J:153656 )
• 67% of tumors are T cell lymphomas




Genotype
MGI:3613060
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+
TgTn(sb-T2/Onc2)6070Njen/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(sb11)Njen mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
TgTn(sb-T2/Onc2)6070Njen mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:102234 )
• all mice that survive past weaning die by 17 weeks of age from cancer
lethality throughout fetal growth and development, incomplete penetrance ( J:102234 )
• only 12.5% (17 of 136) of pups at birth are double mutants and significant loss of these mice is seen at E16 but not at E10

neoplasm
increased tumor incidence ( J:102234 )
• all double mutants develop cancer with a variety of tumor types
increased lymphoma incidence ( J:102234 )
• non-T/non-B cell derived lymphoma is also seen
increased T cell derived lymphoma incidence ( J:102234 )
• most common type of tumor
increased medulloblastoma incidence ( J:102234 )
• some mice develop medulloblastomas

embryo
decreased embryo size ( J:102234 )
• at E10 and E16, many embryos appear smaller than control littermates

digestive/alimentary system
abnormal duodenum morphology ( J:102234 )
• hyperplasia of the duodenum was seen in 2 mice

growth/size/body
decreased embryo size ( J:102234 )
• at E10 and E16, many embryos appear smaller than control littermates
decreased fetal size ( J:102234 )
• at E16

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:102234 )
• most common type of tumor

nervous system
increased medulloblastoma incidence ( J:102234 )
• some mice develop medulloblastomas

immune system
increased T cell derived lymphoma incidence ( J:102234 )
• most common type of tumor

hematopoietic system
increased T cell derived lymphoma incidence ( J:102234 )
• most common type of tumor




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory