Phenotypes associated with this allele

• Allele Symbol: Ghsr^tm1Lowl
• Allele Name: targeted mutation 1, Bradford B Lowell
• Allele ID: MGI:3613057
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ghsr^tm1Lowl/Ghsr^tm1Lowl	involves: C57BL/6J	MGI:3613739

Genotype
MGI:3613739

hm1

• Allelic Composition: Ghsr^tm1Lowl/Ghsr^tm1Lowl
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:104704 )

• blood glucose levels are lower in males after 19 weeks on a standard chow diet

abnormal energy expenditure ( J:104704 )

• lower gross energetic efficiencies (energy gain per kilocalorie of food consumed)

decreased susceptibility to diet-induced obesity ( J:104704 )

• after 8 weeks on a high-fat diet, females weigh 12.7% less and have 46.5% less fat mass than controls, however leptin levels are normal

• after 8 weeks of a high-fat diet, males weigh 10.9% less and have 16.5% less fat mass than controls, however leptin levels are normal

decreased respiratory quotient ( J:104704 )

• significant reduction in respiratory quotient, but not in oxygen consumption, after 19 weeks on a high-fat diet

abnormal response/metabolism to endogenous compounds ( J:104704 )

• ghrelin administration fails to stimulate food intake and to activate arcuate nucleus neurons

growth/size/body

decreased body weight ( J:104704 )

• females, but not males, on standard chow diet for 19 weeks weigh 11.7% less than wild-type

decreased susceptibility to diet-induced obesity ( J:104704 )

• after 8 weeks on a high-fat diet, females weigh 12.7% less and have 46.5% less fat mass than controls, however leptin levels are normal

• after 8 weeks of a high-fat diet, males weigh 10.9% less and have 16.5% less fat mass than controls, however leptin levels are normal

adipose tissue

decreased total body fat amount ( J:104704 )

• females on a standard chow diet for 19 weeks have 35.6% less body fat than wild-type, however show no differences in lean mass

behavior/neurological

decreased food intake ( J:104704 )

• reduction in mean weekly food intake when fed a high-fat diet

• lower feed efficiencies (weight gain per kilocalorie of food consumed)

decreased locomotor activity ( J:104704 )

• significant decrease in locomotor activity, especially during the dark cycle, after 19 weeks on a high-fat diet