Analysis Tools
immune system
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• reduction in the recruitment of macrophages to wound sites
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• 38% increase in the number of T cells that adhere to an ICAM-1 coated surface
• 41% and 27% reduction in chemotactic migration of T cells toward SDF-1alpha after 2 and 4 hours of adhesion, respectively
• reduction in the recruitment of T cells to wound sites
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cellular
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• primary dermal fibroblasts have an increase in the number of actin stress fibers and vinculin-positive focal adhesion contacts, however see no alterations in tubulin and vimentin network
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• reduction in the recruitment of macrophages to wound sites
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• in an in vitro wound healing assay, primary dermal fibroblasts migrate considerably slower than wild-type
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• chemotaxis of primary dermal fibroblasts towards PDGF in a Boyden chamber is reduced to 60%
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homeostasis/metabolism
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• by day 5 after wounding, a lower cell density is observed at wound sites, however this difference is hardly noticeable by 7 and 10 days
• reduction in the recruitment of macrophages and T cells, but not neutrophils, to wound sites
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• in an in vitro wound healing assay, primary dermal fibroblasts migrate considerably slower than wild-type
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muscle
| N |
• no obvious pathologies in the soleus at 1 year of age
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integument
| N |
• do not exhibit skin defects such as skin blistering that is seen in Plec1 null mice
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hematopoietic system
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• reduction in the recruitment of macrophages to wound sites
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• 38% increase in the number of T cells that adhere to an ICAM-1 coated surface
• 41% and 27% reduction in chemotactic migration of T cells toward SDF-1alpha after 2 and 4 hours of adhesion, respectively
• reduction in the recruitment of T cells to wound sites
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