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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smtntm2Gve
targeted mutation 2, Guillaume van Eys
MGI:3613293
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smtntm2Gve/Smtntm2Gve B6.129-Smtntm2Gve MGI:4438895
hm2
Smtntm2Gve/Smtntm2Gve involves: 129/Sv * C57BL/6 MGI:3614256


Genotype
MGI:4438895
hm1
Allelic
Composition
Smtntm2Gve/Smtntm2Gve
Genetic
Background
B6.129-Smtntm2Gve
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smtntm2Gve mutation (0 available); any Smtn mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased heart weight to body weight ratio at 8 months of age
• both the left and right ventricular walls are enlarged by morphometric analysis and expression analysis shows upregulation of hypertrophy markers
• increase in the cross sectional area of both the left and right ventricular walls
• mean arterial pressure responses to intravenous bolus injections of phenylephrine are reduced
• almost 2-fold greater distension of the aorta during the cardiac cycle by magnetic resonance imaging
• the maximal contractions produced by the saphenous arteries are strongly and significantly decreased in response to K+ , the thromboxane A2 mimetic U46619, or the alpha1 1 adrenergic agonist, phenylephrine
• contractility of the femoral artery in response to K+ and phenylephrine is reduced

muscle
• the maximal contractions produced by the saphenous arteries are strongly and significantly decreased in response to K+ , the thromboxane A2 mimetic U46619, or the alpha1 1 adrenergic agonist, phenylephrine
• contractility of the femoral artery in response to K+ and phenylephrine is reduced

growth/size/body
• both the left and right ventricular walls are enlarged by morphometric analysis and expression analysis shows upregulation of hypertrophy markers




Genotype
MGI:3614256
hm2
Allelic
Composition
Smtntm2Gve/Smtntm2Gve
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smtntm2Gve mutation (0 available); any Smtn mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• exhibit no overt abnormalities, no intestinal abnormalities, have normal fat disposition, are fertile, and have a normal life span





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory