cardiovascular system
• increased heart weight to body weight ratio at 8 months of age
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• both the left and right ventricular walls are enlarged by morphometric analysis and expression analysis shows upregulation of hypertrophy markers
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• increase in the cross sectional area of both the left and right ventricular walls
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• mean arterial pressure responses to intravenous bolus injections of phenylephrine are reduced
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• almost 2-fold greater distension of the aorta during the cardiac cycle by magnetic resonance imaging
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• the maximal contractions produced by the saphenous arteries are strongly and significantly decreased in response to K+ , the thromboxane A2 mimetic U46619, or the alpha1 1 adrenergic agonist, phenylephrine
• contractility of the femoral artery in response to K+ and phenylephrine is reduced
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muscle
• the maximal contractions produced by the saphenous arteries are strongly and significantly decreased in response to K+ , the thromboxane A2 mimetic U46619, or the alpha1 1 adrenergic agonist, phenylephrine
• contractility of the femoral artery in response to K+ and phenylephrine is reduced
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growth/size/body
• both the left and right ventricular walls are enlarged by morphometric analysis and expression analysis shows upregulation of hypertrophy markers
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