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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr5tm1Blck
targeted mutation 1, Bruno Luckow
MGI:3613371
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr5tm1Blck/Ccr5tm1Blck B6.129P2-Ccr5tm1Blck MGI:3614447
cx2
 		Apoetm1Unc/Apoetm1Unc
Ccr5tm1Blck/Ccr5tm1Blck 		involves: 129P2/OlaHsd * C57BL/6 MGI:5317846


Genotype
MGI:3614447
hm1
Allelic
Composition		 Ccr5tm1Blck/Ccr5tm1Blck
Genetic
Background		 B6.129P2-Ccr5tm1Blck
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5tm1Blck mutation (7 available); any Ccr5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal response to cardiac infarction ( J:104744 )
• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

immune system
abnormal cellular extravasation ( J:104744 )
• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
abnormal leukocyte adhesion ( J:104744 )
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes
increased length of allograft survival ( J:105072 )
• survival of transplated cardiac allographs from BALB/c mice into homozygotes is significantly increased and allografts show less tissue remodeling and hence better preservation of myocardial architecture
• carotid artery allografts from BALB/c mice into homozygotes show better tissue preservation and significant reduction of neointima formation and CD3+ T cell infiltration

homeostasis/metabolism
abnormal response to cardiac infarction ( J:104744 )
• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

cellular
abnormal cellular extravasation ( J:104744 )
• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
abnormal leukocyte adhesion ( J:104744 )
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes

hematopoietic system
abnormal cellular extravasation ( J:104744 )
• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
abnormal leukocyte adhesion ( J:104744 )
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes




Genotype
MGI:5317846
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Ccr5tm1Blck/Ccr5tm1Blck
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Ccr5tm1Blck mutation (7 available); any Ccr5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:128063 )
• reduced plaque areas after 10-12 weeks on a high fat or high cholesterol diet
• both in the aortic root and the thoracoabdominal artery
• also at 22 weeks when fed a normal diet

immune system
decreased T cell number ( J:128063 )
• in atherosclerotic plaques reduced 24% compared to Apoetm1Unc
abnormal mononuclear phagocyte morphology ( J:128063 )
• monocyte/macrophage in atherosclerotic plaques reduced 77% compared to Apoetm1Unc
abnormal lymphocyte physiology ( J:128063 )
• reduced proliferative responses of splenocytes and of lymph node cells by 25% compared to Apoetm1Unc
decreased interferon-gamma secretion ( J:128063 )
• significantly decreased secretion by splenocytes
increased interleukin-10 secretion ( J:128063 )
• increased content in atherosclerotic plaques
• increased secretion by both splenocytes and by lymph node cells

hematopoietic system
decreased T cell number ( J:128063 )
• in atherosclerotic plaques reduced 24% compared to Apoetm1Unc
abnormal mononuclear phagocyte morphology ( J:128063 )
• monocyte/macrophage in atherosclerotic plaques reduced 77% compared to Apoetm1Unc
abnormal lymphocyte physiology ( J:128063 )
• reduced proliferative responses of splenocytes and of lymph node cells by 25% compared to Apoetm1Unc




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
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