Phenotypes associated with this allele

• Allele Symbol: Ccr2^tm1Blck
• Allele Name: targeted mutation 1, Bruno Luckow
• Allele ID: MGI:3613374
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccr2^tm1Blck/Ccr2^tm1Blck	B6.129P2-Ccr2^tm1Blck	MGI:3614445
cx2	Ccr2^tm1Blck/Ccr2^tm1Blck Fas^lpr/Fas^lpr	MRL.Cg-Ccr2^tm1Blck Fas^lpr	MGI:3665495

Genotype
MGI:3614445

hm1

• Allelic Composition: Ccr2^tm1Blck/Ccr2^tm1Blck
• Genetic Background: B6.129P2-Ccr2^tm1Blck

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal response to cardiac infarction ( J:104744 )

• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

immune system

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 63.7% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

• at 120 min of reperfusion, but not at 5 min, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes

homeostasis/metabolism

abnormal response to cardiac infarction ( J:104744 )

• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

cellular

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 63.7% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

• at 120 min of reperfusion, but not at 5 min, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes

hematopoietic system

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 63.7% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

• at 120 min of reperfusion, but not at 5 min, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes

Genotype
MGI:3665495

cx2

• Allelic Composition: Ccr2^tm1Blck/Ccr2^tm1Blck; Fas^lpr/Fas^lpr
• Genetic Background: MRL.Cg-Ccr2^tm1Blck Fas^lpr

mortality/aging

premature death ( J:113343 )

• life span is considerably reduced on average but considerably longer than Fas^lpr controls

immune system

abnormal lymphocyte cell number ( J:113343 )

• frequency of CD4+ T cells in peripheral blood is significantly reduced relative to Fas^lpr controls

• percentage of CD8+ T cells is markedly reduced at 14 and 20 weeks of age relative to Fas^lpr controls

abnormal interferon level ( J:113343 )

• levels significantly reduced relative to Fas^lpr controls

abnormal tumor necrosis factor level ( J:113343 )

• levels significantly reduced relative to Fas^lpr controls

abnormal immune system organ morphology ( J:113343 )

enlarged spleen ( J:113343 )

• enlargement is significantly less at 14 weeks of age than in Fas^lpr controls

• spleen enlargement at 20 weeks equivalent to controls

enlarged lymph nodes ( J:113343 )

• enlargement is significantly less than in Fas^lpr controls

kidney inflammation ( J:113343 )

• less T-cell and macrophage infiltration than in Fas^lpr controls

glomerulonephritis ( J:113343 )

• not as extensive as in Fas^lpr controls

renal/urinary system

albuminuria ( J:113343 )

• significantly less developed at 8 and 14 weeks but comparable to Fas^lpr controls at 20 weeks

kidney inflammation ( J:113343 )

• less T-cell and macrophage infiltration than in Fas^lpr controls

glomerulonephritis ( J:113343 )

• not as extensive as in Fas^lpr controls

abnormal renal glomerulus morphology ( J:113343 )

• abnormalities much less than in Fas^lpr controls

• abnormalities seen at 14 weeks of age include hypercellular glomeruli, increased mesangial matrix, and perivascular lymphoid cell accumulations

expanded mesangial matrix ( J:113343 )

• increased mesangial matrix at 14 weeks of age

glomerulosclerosis ( J:113343 )

• intraglomerular necrosis and sclerosis less developed than in Fas^lpr controls

renal tubule atrophy ( J:113343 )

• tubular damage and atrophy less than in Fas^lpr controls

hematopoietic system

enlarged spleen ( J:113343 )

• enlargement is significantly less at 14 weeks of age than in Fas^lpr controls

• spleen enlargement at 20 weeks equivalent to controls

abnormal lymphocyte cell number ( J:113343 )

• frequency of CD4+ T cells in peripheral blood is significantly reduced relative to Fas^lpr controls

• percentage of CD8+ T cells is markedly reduced at 14 and 20 weeks of age relative to Fas^lpr controls

homeostasis/metabolism

abnormal interferon level ( J:113343 )

• levels significantly reduced relative to Fas^lpr controls

abnormal tumor necrosis factor level ( J:113343 )

• levels significantly reduced relative to Fas^lpr controls

albuminuria ( J:113343 )

• significantly less developed at 8 and 14 weeks but comparable to Fas^lpr controls at 20 weeks

growth/size/body

enlarged spleen ( J:113343 )

• enlargement is significantly less at 14 weeks of age than in Fas^lpr controls

• spleen enlargement at 20 weeks equivalent to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:113343