Phenotypes associated with this allele

• Allele Symbol: Tnfsf12^tm1Ash
• Allele Name: targeted mutation 1, Avi Ashikenazi
• Allele ID: MGI:3613442
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf12^tm1Ash/Tnfsf12^tm1Ash	B6.129-Tnfsf12^tm1Ash	MGI:3613556

Genotype
MGI:3613556

hm1

• Allelic Composition: Tnfsf12^tm1Ash/Tnfsf12^tm1Ash
• Genetic Background: B6.129-Tnfsf12^tm1Ash

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte morphology ( J:104801 )

increased double-positive T cell number ( J:104801 )

• increased numbers of CD4+ and CD8+ cells in older mice

increased NK cell number ( J:104801 )

• increased numbers, most obviously in secondary lymph nodes

• NK cells in bone marrow unaffected

• numbers of NKT cells not increased

increased T-helper 1 cell number ( J:104801 )

• increased numbers in the spleen

increased memory T cell number ( J:104801 )

• increased numbers in the spleen

abnormal immune system organ morphology ( J:104801 )

enlarged spleen ( J:104801 )

• by 6 months of age

• increased numbers of CD4 and CD8 positive cells

• splenic NK cells increased in number

• most spleen enlargement due to T cell expansion

enlarged lymph nodes ( J:104801 )

• by 6 months of age

abnormal cytokine secretion ( J:104801 )

increased interferon-gamma secretion ( J:104801 )

• increased interferon gamma production by NK cells

decreased interleukin-10 secretion ( J:104801 )

• decreased Il-10 production by NK cells

increased interleukin-12 secretion ( J:104801 )

• increased Il-12 production by NK cells

increased susceptibility to bacterial infection ( J:104801 )

• increased susceptibility to lipopolysaccharide induced death

hematopoietic system

enlarged spleen ( J:104801 )

• by 6 months of age

• increased numbers of CD4 and CD8 positive cells

• splenic NK cells increased in number

• most spleen enlargement due to T cell expansion

abnormal leukocyte morphology ( J:104801 )

increased double-positive T cell number ( J:104801 )

• increased numbers of CD4+ and CD8+ cells in older mice

increased NK cell number ( J:104801 )

• NK cells in bone marrow unaffected

• numbers of NKT cells not increased

• increased numbers, most obviously in secondary lymph nodes

increased T-helper 1 cell number ( J:104801 )

• increased numbers in the spleen

increased memory T cell number ( J:104801 )

• increased numbers in the spleen

growth/size/body

enlarged spleen ( J:104801 )

• by 6 months of age

• increased numbers of CD4 and CD8 positive cells

• splenic NK cells increased in number

• most spleen enlargement due to T cell expansion