Phenotypes associated with this allele

• Allele Symbol: Tgfbr1^tm1Spo
• Allele Name: targeted mutation 1, S Paul Oh
• Allele ID: MGI:3613461
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfbr1^tm1Spo/Tgfbr1^tm1Spo	either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)	MGI:3613536

Genotype
MGI:3613536

hm1

• Allelic Composition: Tgfbr1^tm1Spo/Tgfbr1^tm1Spo
• Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104918 )

• embryos die around E9.5 to E10.5

embryo

embryonic growth retardation ( J:104918 )

• embryo proper retarded to a mild or severe extent at E10.5

excessive folding of visceral yolk sac ( J:104918 )

• wrinkled in appearance at E9.5

abnormal vitelline vascular remodeling ( J:104918 )

• no visible blood filled vessels at E9.5

• mature vasculature lacking at E10.5

cardiovascular system

abnormal vascular smooth muscle morphology ( J:104918 )

• although vascular networks appear normal at E9.5 and blood vessels are of normal shape and size, vascular smooth muscle development is defective

muscle

abnormal vascular smooth muscle morphology ( J:104918 )

• although vascular networks appear normal at E9.5 and blood vessels are of normal shape and size, vascular smooth muscle development is defective

growth/size/body

embryonic growth retardation ( J:104918 )

• embryo proper retarded to a mild or severe extent at E10.5