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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cntn6tm1Kwat
targeted mutation 1, Kazutada Watanabe
MGI:3613462
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cntn6tm1Kwat/Cntn6tm1Kwat involves: 129X1/SvJ * C57BL/6 MGI:3613527
ht2
 		Cntn6tm1Kwat/Cntn6+ involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:3820311
cx3
 		Chl1tm1Mtg/Chl1+
Cntn6tm1Kwat/Cntn6+ 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:3820310
cx4
 		Cntn6tm1Kwat/Cntn6tm1Kwat
Tg(Thy1-YFP)HJrs/0 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:3820309


Genotype
MGI:3613527
hm1
Allelic
Composition		 Cntn6tm1Kwat/Cntn6tm1Kwat
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn6tm1Kwat mutation (1 available); any Cntn6 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:104862 )
N
• brain size as well as body size normal
• brain cytoarchitecture normal
• normal excitatory synaptic function in the cerebellum

behavior/neurological
impaired coordination ( J:104862 )
• as measured in a rotarod test, a stationary horizontal balance rod, and hanging wire test




Genotype
MGI:3820311
ht2
Allelic
Composition		 Cntn6tm1Kwat/Cntn6+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn6tm1Kwat mutation (1 available); any Cntn6 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex pyramidal cell morphology ( J:130375 )
• mutants exhibit misorientation of apical dendrites in layer V pyramidal neurons in the visual cortex




Genotype
MGI:3820310
cx3
Allelic
Composition		 Chl1tm1Mtg/Chl1+
Cntn6tm1Kwat/Cntn6+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chl1tm1Mtg mutation (0 available); any Chl1 mutation (57 available)
Cntn6tm1Kwat mutation (1 available); any Cntn6 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex pyramidal cell morphology ( J:130375 )
• mutants exhibit a more severe misorientation of apical dendrites in layer V pyramidal neurons in the visual cortex than seen in either heterozygous mouse




Genotype
MGI:3820309
cx4
Allelic
Composition		 Cntn6tm1Kwat/Cntn6tm1Kwat
Tg(Thy1-YFP)HJrs/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn6tm1Kwat mutation (1 available); any Cntn6 mutation (64 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex pyramidal cell morphology ( J:130375 )
• mutants exhibit misorientation of apical dendrites in layer V pyramidal neurons in the visual cortex, but not in motor, somatosensory, or auditory cortices or in the upper layer of the visual cortex




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory