Phenotypes associated with this allele

• Allele Symbol: Hif1a^tm1.1Mcs
• Allele Name: targeted mutation 1.1, M Celeste Simon
• Allele ID: MGI:3613538
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hif1a^tm1.1Mcs/Hif1a^tm1.1Mcs	involves: 129S6/SvEvTac	MGI:3618332
ht2	Hif1a^tm1.1Mcs/Hif1a^+	involves: 129S6/SvEvTac	MGI:3618335

Genotype
MGI:3618332

hm1

• Allelic Composition: Hif1a^tm1.1Mcs/Hif1a^tm1.1Mcs
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:105812 )

• about 2/3 cannot be recovered at E6.5-E7.5

embryo

abnormal embryo development ( J:105812 )

• 10% of E6.5-E7.5 embryos fail to form typical extraembryonic and embryonic cavities

abnormal developmental patterning ( J:105812 )

• aberrant temporal and spatial expression of mesodermal and visceral endoderm markers, suggesting that embryos fail to maintain normal patterning of embryonic and extraembryonic tissues

embryonic growth arrest ( J:105812 )

• arrest development around the time of mesoderm formation

abnormal embryonic epiblast morphology ( J:105812 )

• improper formation of the epiblast

• 10% of E6.5-E7.5 embryos exhibit an expansion of the epiblast

Genotype
MGI:3618335

ht2

• Allelic Composition: Hif1a^tm1.1Mcs/Hif1a⁺
• Genetic Background: involves: 129S6/SvEvTac

mortality/aging

prenatal lethality, incomplete penetrance ( J:105812 )

• although the majority of observed phenotypes do not result in lethality, some embryos do die (stage not specified)

embryo

abnormal embryo development ( J:105812 )

• between E10.5 and E13.5, about 50% of heterozygotes exhibit various developmental defects

cardiovascular system

pericardial effusion ( J:105812 )

• some embryos exhibit cardiac effusion

hemorrhage ( J:105812 )

• some E13.5 embryos exhibit minor hemorrhaging in the embryo and yolk sac

homeostasis/metabolism

pericardial effusion ( J:105812 )

• some embryos exhibit cardiac effusion