Phenotypes associated with this allele

• Allele Symbol: Ppp2ca^tm1Gotz
• Allele Name: targeted mutation 1, Jurgen Gotz
• Allele ID: MGI:3613579
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp2ca^tm1Gotz/Ppp2ca^tm1Gotz	involves: 129/Sv * C57BL/6	MGI:3614402

Genotype
MGI:3614402

hm1

• Allelic Composition: Ppp2ca^tm1Gotz/Ppp2ca^tm1Gotz
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:50519 )

• embryos appear to develop normally until E5.5/6.0 and appear degenerated thereafter

embryo

embryo phenotype ( J:50519 )

N • at E3.5, embryos appear morphologically normal

N • at E6.5, defined layers of extraembryonic and embryonic ectoderm and extraembryonic and embryonic endoderm are present and have formed normally

N • blasctocysts display a normal morphology of the inner cell mass and of the trophectoderm

N • implantation proceeds normally

decreased embryo size ( J:50519 )

• after E6.5, embryos appear smaller than controls and show signs of degeneration

abnormal embryonic tissue morphology ( J:50519 )

• after E6.5, all germ layers show signs of degeneration

• some homozygous cell masses are still present at E13.5 suggesting that part of the embryo is still capable of proliferation, while differentiation is impaired

absent mesoderm ( J:50519 )

• absence of mesoderm at E6.5 was determined by lack of immunohistochemical staining for brachyury and goosecoid, early mesodermal markers

growth/size/body

decreased embryo size ( J:50519 )

• after E6.5, embryos appear smaller than controls and show signs of degeneration