Phenotypes associated with this allele

• Allele Symbol: Abi1^tm1Pen
• Allele Name: targeted mutation 1, Ann Marie Pendergast
• Allele ID: MGI:3613611
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abi1^tm1Pen/Abi1^tm1Pen	involves: C57BL/6	MGI:4941221
hm2	Abi1^tm1Pen/Abi1^tm1Pen	involves: CD-1	MGI:4941220
hm3	Abi1^tm1Pen/Abi1^tm1Pen	Not Specified	MGI:4358258
cx4	Abi1^tm1Pen/Abi1^+ Abi2^tm1Pen/Abi2^tm1Pen	Not Specified	MGI:4358259
cx5	Abi1^tm1Pen/Abi1^tm1Pen Abi2^tm1Pen/Abi2^+	Not Specified	MGI:4941219

Genotype
MGI:4941221

hm1

• Allelic Composition: Abi1^tm1Pen/Abi1^tm1Pen
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:169009 )

• mice die between E8.5 and E11.5

embryo

embryonic growth retardation ( J:169009 )

• at E8.5

abnormal chorion morphology ( J:169009 )

• impaired vasculogenesis is indicated by the allantois that appears compact and lacks spaces at the distal tip compared to in wild-type mice

failure of chorioallantoic fusion ( J:169009 )

cardiovascular system

abnormal vasculogenesis ( J:169009 )

• impaired vasculogenesis is indicated by the allantois that appears compact and lacks spaces at the distal tip compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:169009 )

• at E8.5

Genotype
MGI:4941220

hm2

• Allelic Composition: Abi1^tm1Pen/Abi1^tm1Pen
• Genetic Background: involves: CD-1

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169009 )

• mice die between E9.5 and E13.5

cardiovascular system

decreased angiogenesis ( J:169009 )

• in the yolk sac

abnormal vitelline vasculature morphology ( J:169009 )

• mice exhibit reduced angiogenesis in the yolk sac compared with wild-type mice

abnormal heart layer morphology ( J:169009 )

• disrupted at E10.5

disorganized myocardium ( J:169009 )

abnormal endocardium morphology ( J:169009 )

• discontinuous

abnormal epicardium morphology ( J:169009 )

• disorganized

internal hemorrhage ( J:169009 )

• around the heart

embryo

abnormal vitelline vasculature morphology ( J:169009 )

• mice exhibit reduced angiogenesis in the yolk sac compared with wild-type mice

embryonic growth retardation ( J:169009 )

• at E9.5

abnormal chorion morphology ( J:169009 )

• by E9.5, the chorion appears compact and button-like unlike in wild-type mice

increased Reichert's membrane thickness ( J:169009 )

• the basement membrane associated with Reichert's membrane is thickened compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:169009 )

• at E9.5

homeostasis/metabolism

edema ( J:169009 )

• around the heart

muscle

disorganized myocardium ( J:169009 )

Genotype
MGI:4358258

hm3

• Allelic Composition: Abi1^tm1Pen/Abi1^tm1Pen
• Genetic Background: Not Specified

mortality/aging

embryonic lethality, complete penetrance ( J:104623 )

• mice die before E9.5

Genotype
MGI:4358259

cx4

• Allelic Composition: Abi1^tm1Pen/Abi1⁺; Abi2^tm1Pen/Abi2^tm1Pen
• Genetic Background: Not Specified

hematopoietic system

decreased T cell proliferation ( J:104623 )

• TCR-induced primary T cell proliferation is decreased 60% compared to similarly treated wild-type cells

• however, treatment with IL2 partially restores primary T cell proliferation

• TCR-induced T cell proliferation is reduced 60% to 70% in the spleen and thymus compared with similarly treated wild-type mice even in the presence of IL12

immune system

immune system phenotype ( J:104623 )

N

decreased T cell proliferation ( J:104623 )

• TCR-induced primary T cell proliferation is decreased 60% compared to similarly treated wild-type cells

• however, treatment with IL2 partially restores primary T cell proliferation

• TCR-induced T cell proliferation is reduced 60% to 70% in the spleen and thymus compared with similarly treated wild-type mice even in the presence of IL12

decreased interleukin-2 secretion ( J:104623 )

• when T cells are stimulated with anti-CD3 mediated

cellular

decreased T cell proliferation ( J:104623 )

• TCR-induced primary T cell proliferation is decreased 60% compared to similarly treated wild-type cells

• however, treatment with IL2 partially restores primary T cell proliferation

• TCR-induced T cell proliferation is reduced 60% to 70% in the spleen and thymus compared with similarly treated wild-type mice even in the presence of IL12

Genotype
MGI:4941219

cx5

• Allelic Composition: Abi1^tm1Pen/Abi1^tm1Pen; Abi2^tm1Pen/Abi2⁺
• Genetic Background: Not Specified

cellular

abnormal cell physiology ( J:169009 )

• mouse embryonic fibroblasts exhibit defective spreading on fibronectin compared with wild-type cells