All Phenotypes Sall4<Gt(W097E01)Flo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sall4^{Gt(W097E01)Flo}
gene trap W097E01, Thomas Floss
MGI:3613746

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sall4^{Gt(W097E01)Flo}/Sall4^{Gt(W097E01)Flo}	involves: 129S2/SvPas * C57BL/6	MGI:3809919
cx2	Sall1^tm1Jkoh/Sall1^tm1Jkoh Sall4^{Gt(W097E01)Flo}/Sall4⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3828113
cx3	Sall2^tm1Jkoh/Sall2⁺ Sall4^{Gt(W097E01)Flo}/Sall4⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3828135
cx4	Sall1^tm1Jkoh/Sall1⁺ Sall4^{Gt(W097E01)Flo}/Sall4⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3828112
cx5	Ctnnb1^tm2.1Kem/Ctnnb1⁺ Sall4^{Gt(W097E01)Flo}/Sall4⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3809920
cx6	Sall2^tm1Jkoh/Sall2^tm1Jkoh Sall4^{Gt(W097E01)Flo}/Sall4⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J	MGI:3828134

Allelic Composition	Sall4^{Gt(W097E01)Flo}/Sall4^{Gt(W097E01)Flo}
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall4^{Gt(W097E01)Flo} mutation (0 available); any Sall4 mutation (145 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:138922 )

• die around E7.5

embryo

abnormal developmental patterning ( J:138922 )

• expression analysis detects patterning defects prior to gastrulation including defects in patterning of the extraembryonic ectoderm by E5.5

abnormal gastrulation ( J:138922 )

• primitive streak formation is visible but mesoderm fails to reach the anterior or lateral limits instead accumulating on the posterior side

abnormal mesendoderm development ( J:138922 )

• expression analysis indicates a deficit in anterior mesendoderm

abnormal rostral-caudal body axis extension ( J:138922 )

• tetraploid rescue allows embryos to survive past gastrulation but these embryos show severe posterior axis truncations at E9.5

embryonic growth arrest ( J:138922 )

• arrest around E7.5

decreased embryo size ( J:138922 )

• at E7.5

abnormal embryonic epiblast morphology ( J:138922 )

• polarity is disturbed

small embryonic epiblast ( J:138922 )

• appears smaller

absent primitive node ( J:138922 )

• no sign of node formation at E7.5

growth/size/body

decreased embryo size ( J:138922 )

• at E7.5

Allelic Composition	Sall1^tm1Jkoh/Sall1^tm1Jkoh Sall4^{Gt(W097E01)Flo}/Sall4⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm1Jkoh mutation (0 available); any Sall1 mutation (78 available)
Sall4^{Gt(W097E01)Flo} mutation (0 available); any Sall4 mutation (145 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:143350 )

• die at about E11.5

embryo

embryonic growth retardation ( J:143350 )

• general growth retardation is seen at E10.5

open neural tube ( J:143350 )

• full penetrance of neural tube defects

nervous system

open neural tube ( J:143350 )

• full penetrance of neural tube defects

growth/size/body

embryonic growth retardation ( J:143350 )

• general growth retardation is seen at E10.5

Allelic Composition	Sall2^tm1Jkoh/Sall2⁺ Sall4^{Gt(W097E01)Flo}/Sall4⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2^tm1Jkoh mutation (0 available); any Sall2 mutation (51 available)
Sall4^{Gt(W097E01)Flo} mutation (0 available); any Sall4 mutation (145 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

open neural tube ( J:143350 )

• partial penetrance of neural tube defects

embryo

open neural tube ( J:143350 )

• partial penetrance of neural tube defects

mortality/aging

perinatal lethality, incomplete penetrance ( J:143350 )

Allelic Composition	Sall1^tm1Jkoh/Sall1⁺ Sall4^{Gt(W097E01)Flo}/Sall4⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:143350 )

• only 4 of 79 offspring of heterozygous crosses were compound heterozygotes

nervous system

open neural tube ( J:143350 )

• partial penetrance of neural tube defects

embryo

open neural tube ( J:143350 )

• partial penetrance of neural tube defects

Allelic Composition	Ctnnb1^tm2.1Kem/Ctnnb1⁺ Sall4^{Gt(W097E01)Flo}/Sall4⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2.1Kem mutation (0 available); any Ctnnb1 mutation (49 available)
Sall4^{Gt(W097E01)Flo} mutation (0 available); any Sall4 mutation (145 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:138922 )

• absent at weaning possibly indicating embryonic lethality

embryo

abnormal mesoderm development ( J:138922 )

• expression analysis indicates impaired mesoderm development

embryonic growth retardation ( J:138922 )

• at E7.5

abnormal anterior primitive streak morphology ( J:138922 )

• a gap in T expression is seen in the anterior primitive streak between E7.5 and E7.75 in the area where cells fate mapped to give rise to paraxial mesoderm are found

growth/size/body

embryonic growth retardation ( J:138922 )

• at E7.5

Allelic Composition	Sall2^tm1Jkoh/Sall2^tm1Jkoh Sall4^{Gt(W097E01)Flo}/Sall4⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased embryonic neuroepithelium apoptosis ( J:143350 )

• increase in the number of apoptotic cells at the 9 to 13 somite stage

incomplete rostral neuropore closure ( J:143350 )

• full penetrance of neural tube defects

• at E9.5 the forebrain and midbrain neural folds are not fused

embryo

abnormal neural fold elevation formation ( J:143350 )

• at the 11 somite stage elevation of the neural folds in the cephalic region is reduced and distance between the tips is increased compared to controls

• at the 13 somite stage bending of the neural folds is similar to the 11 somite stage and the tips are far apart

incomplete rostral neuropore closure ( J:143350 )

• full penetrance of neural tube defects

• at E9.5 the forebrain and midbrain neural folds are not fused

mortality/aging

perinatal lethality, incomplete penetrance ( J:143350 )

cellular

increased embryonic neuroepithelium apoptosis ( J:143350 )

• increase in the number of apoptotic cells at the 9 to 13 somite stage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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