Analysis Tools
mortality/aging
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• of mice that survive the embryonic and neonatal period, most died before P5 from intraabdominal bleeding and some survived as long as P19
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• incomplete penetrance; of homozygous mice that are born, 50% die within one day of birth, presumably due to widespread hemorrhage
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• incomplete penetrance; normal Mendelian ratios are present at E9.5, but at E12.5, only 17% of the embryos are homozygous
• resorbed embryos at E9.5 are of all genotypes; at E11.5-12.5, most of the resorbed embryos are homozygous and appear variably as totally disintegrated embryos to nearly normal but white and avascular
• the proportion of homozygous embryos remained constant after E12.5 (16%) until birth
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cardiovascular system
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• no abnormalities in organ or blood vessel development are detected by histochemical analysis
• normal vasculature is observed in E9.5 embryos and their yolk sacs
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• embryos that die at E11.5-E12.5 show overt signs of bleeding, including one with massive blood accumulation in the brain ventricles and along the central canal
• postnatal lethality of homozygotes is presumably due to widespread hemorrhages, most frequently intraabdominal bleeding; other areas include subcutaneous, intracranial, peritoneal and dermal bleeding sites
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