All Phenotypes Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor/? Tg(MMTV-PyVTY315FY322F)Db-1Mul/?	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:3615252
cn2	Ets2^tm3Rgo/Ets2⁺ Meox2^tm1(cre)Sor/? Tg(MMTV-PyVTY315FY322F)Db-1Mul/?	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:3615263
tg3	Tg(MMTV-PyVTY315FY322F)Db-1Mul/?	FVB/N-Tg(MMTV-PyVTY315FY322F)Db-1Mul	MGI:3614342

Allelic Composition	Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor/? Tg(MMTV-PyVTY315FY322F)Db-1Mul/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2^tm3.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Ets2^tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:102368 )

• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group

• once tumors appeared, the rate of tumor growth was not detectably altered

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:102368 )

• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group

• once tumors appeared, the rate of tumor growth was not detectably altered

mammary gland hyperplasia ( J:102368 )

• the epithelial hyperplasia of mutant mice filled less of the mammary fat pad than control

integument

increased mammary gland tumor incidence ( J:102368 )

• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group

• once tumors appeared, the rate of tumor growth was not detectably altered

mammary gland hyperplasia ( J:102368 )

• the epithelial hyperplasia of mutant mice filled less of the mammary fat pad than control

Allelic Composition	Ets2^tm3Rgo/Ets2⁺ Meox2^tm1(cre)Sor/? Tg(MMTV-PyVTY315FY322F)Db-1Mul/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2^tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 137 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 137 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument

increased mammary gland tumor incidence ( J:102368 )

• onset of mammary tumors with a median onset of 137 days

• this mutant was used as control for Ets2^tm3Rgo/Ets2^tm3.1Rgo Meox2^tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:56327 )

• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

• the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

mammary gland hyperplasia ( J:56327 )

• female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals

• the mammary epithelium were incapable of nursing

increased mammary gland apoptosis ( J:56327 )

• mammary epithelial hyperplasias displayed extensive apoptotic cell death

neoplasm

increased mammary adenocarcinoma incidence ( J:56327 )

• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

• the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

integument

increased mammary adenocarcinoma incidence ( J:56327 )

• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

• the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

mammary gland hyperplasia ( J:56327 )

• female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals

• the mammary epithelium were incapable of nursing

increased mammary gland apoptosis ( J:56327 )

• mammary epithelial hyperplasias displayed extensive apoptotic cell death

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:56327

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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