digestive/alimentary system
• cells expressing the transgene fail to develop into mature acinar cells and show increased expression of duct specific genes
• cells expressing the transgene are smaller and more compact with disrupted zymogen granule clustering and reduced amounts of endoplasmic reticulum
• cells not expressing the transgene develop into mature acinar cells
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endocrine/exocrine glands
• cells expressing the transgene fail to develop into mature acinar cells and show increased expression of duct specific genes
• cells expressing the transgene are smaller and more compact with disrupted zymogen granule clustering and reduced amounts of endoplasmic reticulum
• cells not expressing the transgene develop into mature acinar cells
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