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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Olig2tm1Qrlu
targeted mutation 1, Q Richard Lu
MGI:3614399
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Olig2tm1Qrlu/Olig2tm1Qrlu
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3615303
cn2
 		Emx1tm1(cre)Ito/Emx1+
Olig2tm1Qrlu/Olig2tm1Qrlu 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3615304
cn3
 		Olig2tm1Qrlu/Olig2tm1Qrlu
Tg(GFAP-cre)25Mes/? 		involves: 129S4/SvJae * C57BL/6J * FVB/N MGI:3615302


Genotype
MGI:3615303
cn1
Allelic
Composition		 Olig2tm1Qrlu/Olig2tm1Qrlu
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Olig2tm1Qrlu mutation (0 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:105071 )
• no myelination in dorsal cortex while myelination in ventral cortex is normal




Genotype
MGI:3615304
cn2
Allelic
Composition		 Emx1tm1(cre)Ito/Emx1+
Olig2tm1Qrlu/Olig2tm1Qrlu
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Olig2tm1Qrlu mutation (0 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:105071 )
• severe dysmyelination in cortex while ventral forebrain is normal




Genotype
MGI:3615302
cn3
Allelic
Composition		 Olig2tm1Qrlu/Olig2tm1Qrlu
Tg(GFAP-cre)25Mes/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig2tm1Qrlu mutation (0 available); any Olig2 mutation (46 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
limb grasping ( J:105071 )
• abnormal limb clasping reflex
• beginning at 2 weeks of age
tremors ( J:105071 )
• beginning at 2 weeks of age

nervous system
abnormal corpus callosum morphology ( J:105071 )
• severe reduction in numbers of myelinated axons and myelin sheaths are thinner
abnormal oligodendrocyte morphology ( J:105071 )
• development arrested in dorsal cortex before formation of cells capable of forming myelin




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory