About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polhtm1.1Rak
targeted mutation 1.1, Raju Kucherlapati
MGI:3614412
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Polhtm1.1Rak/Polhtm1.1Rak involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3615437
ht2
 		Polhtm1.1Rak/Polh+ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3615446


Genotype
MGI:3615437
hm1
Allelic
Composition		 Polhtm1.1Rak/Polhtm1.1Rak
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm1.1Rak mutation (1 available); any Polh mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal ear pigmentation ( J:105034 )
• ears darken after UV-irradiation due to melanocyte accumulation

pigmentation
abnormal ear pigmentation ( J:105034 )
• ears darken after UV-irradiation due to melanocyte accumulation

neoplasm
increased skin tumor incidence ( J:105034 )
• increased incidence after UV-irradiation
increased squamous cell carcinoma incidence ( J:105034 )
• increased incidence of squamous cell carcinomas after UV-irradiation

craniofacial
abnormal ear pigmentation ( J:105034 )
• ears darken after UV-irradiation due to melanocyte accumulation

integument
abnormal ear pigmentation ( J:105034 )
• ears darken after UV-irradiation due to melanocyte accumulation
increased skin tumor incidence ( J:105034 )
• increased incidence after UV-irradiation

growth/size/body
abnormal ear pigmentation ( J:105034 )
• ears darken after UV-irradiation due to melanocyte accumulation

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
xeroderma pigmentosum variant type DOID:0110847 OMIM:278750
 J:105034




Genotype
MGI:3615446
ht2
Allelic
Composition		 Polhtm1.1Rak/Polh+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm1.1Rak mutation (1 available); any Polh mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:105034 )
• increased susceptibility over wild-type to develop skin tumors
increased incidence of tumors by UV-induction ( J:105034 )
• increased incidence several months after UV-irradiation

integument
increased skin tumor incidence ( J:105034 )
• increased susceptibility over wild-type to develop skin tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory