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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccnd1tm1Phin
targeted mutation 1, Philip W Hinds
MGI:3614415
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccnd1tm1Phin/Ccnd1tm1Phin involves: 129S4/SvJae * C57BL/6 MGI:3614893
cx2
 		Ccnd1tm1Phin/Ccnd1tm1Phin
Ccnd2tm1Wbg/Ccnd2tm1Wbg 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3614894
cx3
 		Ccnd1tm1Phin/Ccnd1tm1Phin
Tg(MMTV-Erbb2)NK1Mul/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3614895


Genotype
MGI:3614893
hm1
Allelic
Composition		 Ccnd1tm1Phin/Ccnd1tm1Phin
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Phin mutation (0 available); any Ccnd1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:105045 )
• body mass of 18-day old male is 61% of that in wild-type
• growth deficiency persists throughout life

vision/eye
abnormal retina morphology ( J:105045 )
• retinas develop relatively normally, being only slightly underdeveloped compared to wild-type
abnormal eye electrophysiology ( J:105045 )
• retinas respond to light with electroretinographic potentials corresponding to about 65% of those seen in wild-type

behavior/neurological
limb grasping ( J:105045 )
• display leg-clasping reflex

reproductive system
reproductive system phenotype ( J:105045 )
N
• normal mammary epithelial expansion, fully developed mammary epithelial trees at the end of pregnancy, and normal lactation




Genotype
MGI:3614894
cx2
Allelic
Composition		 Ccnd1tm1Phin/Ccnd1tm1Phin
Ccnd2tm1Wbg/Ccnd2tm1Wbg
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Phin mutation (0 available); any Ccnd1 mutation (22 available)
Ccnd2tm1Wbg mutation (0 available); any Ccnd2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum development ( J:105045 )
• display severely retarded cerebellar development




Genotype
MGI:3614895
cx3
Allelic
Composition		 Ccnd1tm1Phin/Ccnd1tm1Phin
Tg(MMTV-Erbb2)NK1Mul/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Phin mutation (0 available); any Ccnd1 mutation (22 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:105045 )
• resistant to Erbb2-induced breast cancers

integument
decreased mammary gland tumor incidence ( J:105045 )
• resistant to Erbb2-induced breast cancers

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:105045 )
• resistant to Erbb2-induced breast cancers




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory