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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rettm8(RET)Jmi
targeted mutation 8, Jeffrey Milbrandt
MGI:3614433
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rettm8(RET)Jmi/Rettm8(RET)Jmi involves: 129X1/SvJ * 129S1/Sv * C57BL/6 MGI:3615299


Genotype
MGI:3615299
hm1
Allelic
Composition
Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic
Background
involves: 129X1/SvJ * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm8(RET)Jmi mutation (0 available); any Ret mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• 100% penetrance of multicystic kidneys
• exhibit hypodysplastic kidneys in which normal kidney tissue is absent by P35
• 100% penetrance of bilateral megaureter
• exhibit a decrease in the branching morphogenesis of the ureteric buds
• exhibit bilateral supernumerary ureteric buds that are attached to the wolffian duct

endocrine/exocrine glands
• failure of gonads to separate from Wolffian ducts
• abnormally positioned at P0
• abnormally positioned gonads at P0
• by P35, the testes and the vas deferens are attached to the proximal portion of the dilated ureter

reproductive system
• failure of gonads to separate from Wolffian ducts
• abnormally positioned at P0
• abnormally positioned gonads at P0
• by P35, the testes and the vas deferens are attached to the proximal portion of the dilated ureter
• vas deferens and testes are attached to the proximal portion of the dilated ureter

growth/size/body
• 100% penetrance of multicystic kidneys





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory