renal/urinary system
kidney cyst
(
J:105047
)
• 100% penetrance of multicystic kidneys
|
• exhibit hypodysplastic kidneys in which normal kidney tissue is absent by P35
|
large ureter
(
J:105047
)
• 100% penetrance of bilateral megaureter
|
• exhibit a decrease in the branching morphogenesis of the ureteric buds
|
• exhibit bilateral supernumerary ureteric buds that are attached to the wolffian duct
|
endocrine/exocrine glands
• failure of gonads to separate from Wolffian ducts
• abnormally positioned at P0
|
• abnormally positioned gonads at P0
• by P35, the testes and the vas deferens are attached to the proximal portion of the dilated ureter
|
reproductive system
• failure of gonads to separate from Wolffian ducts
• abnormally positioned at P0
|
• abnormally positioned gonads at P0
• by P35, the testes and the vas deferens are attached to the proximal portion of the dilated ureter
|
• vas deferens and testes are attached to the proximal portion of the dilated ureter
|
growth/size/body
kidney cyst
(
J:105047
)
• 100% penetrance of multicystic kidneys
|