Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rettm11(RET)Jmi targeted mutation 11, Jeffrey Milbrandt MGI:3614441 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• all die by 5 weeks of age
|
|
• show an increase in apoptosis in the kidney at E15.5
|
|
• renal parenchyma is decreased and homozygotes exhibit histopathological changes consistent with obstructive nephropathy
|
|
• multiple cysts of varying sizes are observed at birth as well as later times
|
|
• globally sclerosed glomeruli, indicating end-stage renal histology
|
|
• severe reduction in the number of glomeruli
|
|
• kidneys fail to establish an outer cortex region
|
|
• kidneys fail to establish a normal architecture
• developing glomeruli are seen in embryos but they are scant and scattered throughout the mesenchyme
|
|
• kidneys fail to establish an inner medulla region
|
|
• ectopic kidney is seen by E15.5
|
|
• severe dilation of both ureters
|
|
• distal obstruction in postnatal mice, most likely due to the inability of ureters to separate from the wolffian duct
|
|
• bilateral megaureters with distal stenosis are seen at birth
|
|
• severe decrease in the branching morphogenesis of the ureteric buds
|
|
• exhibit bilateral supernumerary ureteric buds that are attached to the wolffian duct
|
 |
• ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters
|
 |
• testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters
|
|
|
• ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters
|
|
|
• testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters
|
|
• show an increase in apoptosis in the kidney at E15.5
|
|
• multiple cysts of varying sizes are observed at birth as well as later times
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/29/2024 MGI 6.24 |
|
|
|
||
