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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rettm11(RET)Jmi
targeted mutation 11, Jeffrey Milbrandt
MGI:3614441
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rettm11(RET)Jmi/Rettm11(RET)Jmi involves: 129S1/Sv * 129X1/SvJ MGI:3783347
hm2
Rettm11(RET)Jmi/Rettm11(RET)Jmi involves: 129X1/SvJ * 129S1/Sv * C57BL/6 MGI:3615297
ht3
Rettm11(RET)Jmi/Rettm12(RET)Jmi involves: 129S1/Sv * 129X1/SvJ MGI:3783349


Genotype
MGI:3783347
hm1
Allelic
Composition
Rettm11(RET)Jmi/Rettm11(RET)Jmi
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm11(RET)Jmi mutation (0 available); any Ret mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• motor neurons are normal




Genotype
MGI:3615297
hm2
Allelic
Composition
Rettm11(RET)Jmi/Rettm11(RET)Jmi
Genetic
Background
involves: 129X1/SvJ * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm11(RET)Jmi mutation (0 available); any Ret mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all die by 5 weeks of age

renal/urinary system
• show an increase in apoptosis in the kidney at E15.5
• renal parenchyma is decreased and homozygotes exhibit histopathological changes consistent with obstructive nephropathy
• multiple cysts of varying sizes are observed at birth as well as later times
• globally sclerosed glomeruli, indicating end-stage renal histology
• severe reduction in the number of glomeruli
• kidneys fail to establish an outer cortex region
• kidneys fail to establish a normal architecture
• developing glomeruli are seen in embryos but they are scant and scattered throughout the mesenchyme
• kidneys fail to establish an inner medulla region
• ectopic kidney is seen by E15.5
• severe dilation of both ureters
• distal obstruction in postnatal mice, most likely due to the inability of ureters to separate from the wolffian duct
• bilateral megaureters with distal stenosis are seen at birth
• severe decrease in the branching morphogenesis of the ureteric buds
• exhibit bilateral supernumerary ureteric buds that are attached to the wolffian duct

endocrine/exocrine glands
• ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters
• testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters

reproductive system
• ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters
• testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters

cellular
• show an increase in apoptosis in the kidney at E15.5

growth/size/body
• multiple cysts of varying sizes are observed at birth as well as later times




Genotype
MGI:3783349
ht3
Allelic
Composition
Rettm11(RET)Jmi/Rettm12(RET)Jmi
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm11(RET)Jmi mutation (0 available); any Ret mutation (54 available)
Rettm12(RET)Jmi mutation (0 available); any Ret mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory