All Phenotypes Ret<tm12(RET)Jmi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm12(RET)Jmi
targeted mutation 12, Jeffrey Milbrandt
MGI:3614442

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm12(RET)Jmi/Ret^tm12(RET)Jmi	involves: 129S1/Sv * 129X1/SvJ	MGI:3783348
hm2	Ret^tm12(RET)Jmi/Ret^tm12(RET)Jmi	involves: 129X1/SvJ * 129S1/Sv * C57BL/6	MGI:3614977
ht3	Ret^tm11(RET)Jmi/Ret^tm12(RET)Jmi	involves: 129S1/Sv * 129X1/SvJ	MGI:3783349
ht4	Ret^tm9(RET)Jmi/Ret^tm12(RET)Jmi	involves: 129X1/SvJ * 129S1/Sv * C57BL/6	MGI:3615300

Allelic Composition	Ret^tm12(RET)Jmi/Ret^tm12(RET)Jmi
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm12(RET)Jmi mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal muscle spindle morphology ( J:132854 )

abnormal motor neuron innervation pattern ( J:132854 )

decreased motor neuron number ( J:132854 )

muscle

abnormal hypaxial muscle morphology ( J:132854 )

abnormal muscle spindle morphology ( J:132854 )

muscular atrophy ( J:132854 )

Allelic Composition	Ret^tm12(RET)Jmi/Ret^tm12(RET)Jmi
Genetic Background	involves: 129X1/SvJ * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm12(RET)Jmi mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

dilated ureter ( J:105047 )

• very low penetrance (1/60) of unilateral uretral dilation, otherwise are normal

Allelic Composition	Ret^tm11(RET)Jmi/Ret^tm12(RET)Jmi
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm11(RET)Jmi mutation (0 available); any Ret mutation (54 available)
Ret^tm12(RET)Jmi mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal muscle spindle morphology ( J:132854 )

abnormal motor neuron innervation pattern ( J:132854 )

decreased motor neuron number ( J:132854 )

muscle

abnormal hypaxial muscle morphology ( J:132854 )

abnormal muscle spindle morphology ( J:132854 )

muscular atrophy ( J:132854 )

Allelic Composition	Ret^tm9(RET)Jmi/Ret^tm12(RET)Jmi
Genetic Background	involves: 129X1/SvJ * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm12(RET)Jmi mutation (0 available); any Ret mutation (54 available)
Ret^tm9(RET)Jmi mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:105047 )

N	• do not exhibit any major renal abnormalities

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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