Analysis Tools
mortality/aging
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• homozygous mutants have a shorter life span than wild-type controls
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immune system
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• mutant mice develop autoimmune inflammatory bowel disease (IBD) associated with diarrhea and rectal prolapse
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• homozygous mice have a block in B cell development at the transition from the pro- to pre-B cell stage
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• homozygous mutant mice exhibit lymphopenia due to reduction of both Thy1.2+ and B220+ cell numbers
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• homozygotes have reduced numbers of CD8+ T cells
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hematopoietic system
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• homozygous mice have a block in B cell development at the transition from the pro- to pre-B cell stage
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• homozygous mutant mice exhibit lymphopenia due to reduction of both Thy1.2+ and B220+ cell numbers
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• homozygotes have reduced numbers of CD8+ T cells
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digestive/alimentary system
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• mutant mice develop diarrhea associated with autoimmune inflammatory bowel disease
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• mutant mice develop rectal prolapse secondary to autoimmune inflammatory bowel disease
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• mutant mice develop autoimmune inflammatory bowel disease (IBD) associated with diarrhea and rectal prolapse
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