All Phenotypes Zap70<mrtle> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zap70^mrtle/Zap70^mrtle	C57BL/6JSfdAnu-Zap70^mrtle/Apb	MGI:3615426
hm2	Zap70^mrtle/Zap70^mrtle	involves: C57BL/6JSfdAnu	MGI:5576561
ht3	Zap70^mrtle/Zap70^rps	involves: C57BL/6 * C57BL/6JSfdAnu	MGI:5576560

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:104190 )

• failure of positive selection in the thymus

arrested T cell differentiation ( J:104190 )

• normal numbers of both double negative (DN) and double positive (DP) thymocytes in homozygous mutant mice, despite near-absence of both CD4⁺ CD8^- and CD4^- CD8⁺ single positive (SP) T cells in peripheral blood, indicates a block at the transition from the DP to the SP stage, in turn indicating failure of positive selection in the thymus

• the block in mutant T cell develoopment was shown to be cell-intrinsic, not due to the thymic microenvironment

• T cells of mutant mice are unable to pass through thymic selection steps

• T cells of mutant mice fail to up-regulate their TCRs

abnormal T cell subpopulation ratio ( J:104190 )

• although total T cell counts are very low and alpha/beta T cells are virtually absent, gamma/delta T cell numbers are elevated in the peripheral blood of mutant mice

decreased T cell number ( J:104190 )

• homozygous mutant mice are characterized by a severe reduction in the number of T cells in their blood; both CD4⁺ CD8^- and CD4^- CD8⁺ single positive (SP) T cells are almost entirely absent

absent T cells ( J:104190 )

• alpha/beta T cells are absent in the peripheral blood of mutant mice

hematopoietic system

abnormal positive T cell selection ( J:104190 )

• failure of positive selection in the thymus

arrested T cell differentiation ( J:104190 )

• the block in mutant T cell develoopment was shown to be cell-intrinsic, not due to the thymic microenvironment

• T cells of mutant mice are unable to pass through thymic selection steps

• T cells of mutant mice fail to up-regulate their TCRs

abnormal T cell subpopulation ratio ( J:104190 )

• although total T cell counts are very low and alpha/beta T cells are virtually absent, gamma/delta T cell numbers are elevated in the peripheral blood of mutant mice

decreased T cell number ( J:104190 )

• homozygous mutant mice are characterized by a severe reduction in the number of T cells in their blood; both CD4⁺ CD8^- and CD4^- CD8⁺ single positive (SP) T cells are almost entirely absent

absent T cells ( J:104190 )

• alpha/beta T cells are absent in the peripheral blood of mutant mice

Allelic Composition	Zap70^mrtle/Zap70^mrtle
Genetic Background	involves: C57BL/6JSfdAnu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70^mrtle mutation (5 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• absent Foxp3+ regulatory T cells within CD4+ single positive thymocytes and lymphocytes in the spleen

hematopoietic system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• absent Foxp3+ regulatory T cells within CD4+ single positive thymocytes and lymphocytes in the spleen

Allelic Composition	Zap70^mrtle/Zap70^rps
Genetic Background	involves: C57BL/6 * C57BL/6JSfdAnu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70^mrtle mutation (5 available); any Zap70 mutation (55 available)
Zap70^rps mutation (0 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes

• percent of Foxp3+ regulatory T cells within CD4+ single positive lymphocytes in the spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )

• CD4+ T cells exhibit blockage of calcium signaling compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

hematopoietic system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes

• percent of Foxp3+ regulatory T cells within CD4+ single positive lymphocytes in the spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )

• CD4+ T cells exhibit blockage of calcium signaling compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24