Phenotypes associated with this allele

• Allele Symbol: Lcp2^twm
• Allele Name: t-wimp
• Allele ID: MGI:3614800
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lcp2^twm/Lcp2^twm	C57BL/6JSfdAnu-Lcp2^twm/Anu	MGI:3615483

Genotype
MGI:3615483

hm1

• Allelic Composition: Lcp2^twm/Lcp2^twm
• Genetic Background: C57BL/6JSfdAnu-Lcp2^twm/Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal negative T cell selection ( J:104190 )

• mutant T cells have a defect in T cell receptor signaling, resulting in reduced negative thymocyte selection

abnormal positive T cell selection ( J:104190 )

• mutant T cells have a defect in T cell receptor signaling, resulting in defects in positive selection of thymocytes

abnormal double-positive T cell morphology ( J:104190 )

• CD4⁺ CD8⁺ DP thymocytes express very low levels of CD5

arrested T cell differentiation ( J:104190 )

• thymocytes of homozygous mutant mice have a partial block in T cell development at the pre-T cell receptor (pre-TCR) checkpoint

decreased T cell number ( J:104190 )

• homozygous mutant mice have few naive CD4⁺ and CD8⁺ single-positive T cells

decreased thymocyte number ( J:104190 )

• homozygotes have 5-fold fewer CD4⁺ CD8⁺ (DP) and significantly fewer CD4⁺ CD8^- and CD4^- CD8⁺ SP thymocytes than wild-type controls

increased IgE level ( J:104190 )

• homozygous mutant mice exhibit elevated levels of serum IgE

increased IgG level ( J:104190 )

• homozygous mutant mice exhibit hypergammaglobulinemia

abnormal T cell physiology ( J:104190 )

• mutant T cells have a defect in T cell receptor signaling, resulting in defects in positive selection of thymocytes and reduced negative thymocyte selection; this phenotype is cell-intrinsic

autoimmune response ( J:104190 )

• homozygous mutants exhibit autoimmunity

hematopoietic system

abnormal negative T cell selection ( J:104190 )

• mutant T cells have a defect in T cell receptor signaling, resulting in reduced negative thymocyte selection

abnormal positive T cell selection ( J:104190 )

• mutant T cells have a defect in T cell receptor signaling, resulting in defects in positive selection of thymocytes

abnormal double-positive T cell morphology ( J:104190 )

• CD4⁺ CD8⁺ DP thymocytes express very low levels of CD5

arrested T cell differentiation ( J:104190 )

• thymocytes of homozygous mutant mice have a partial block in T cell development at the pre-T cell receptor (pre-TCR) checkpoint

decreased T cell number ( J:104190 )

• homozygous mutant mice have few naive CD4⁺ and CD8⁺ single-positive T cells

decreased thymocyte number ( J:104190 )

• homozygotes have 5-fold fewer CD4⁺ CD8⁺ (DP) and significantly fewer CD4⁺ CD8^- and CD4^- CD8⁺ SP thymocytes than wild-type controls

increased IgE level ( J:104190 )

• homozygous mutant mice exhibit elevated levels of serum IgE

increased IgG level ( J:104190 )

• homozygous mutant mice exhibit hypergammaglobulinemia

abnormal T cell physiology ( J:104190 )

• mutant T cells have a defect in T cell receptor signaling, resulting in defects in positive selection of thymocytes and reduced negative thymocyte selection; this phenotype is cell-intrinsic

endocrine/exocrine glands

decreased thymocyte number ( J:104190 )

• homozygotes have 5-fold fewer CD4⁺ CD8⁺ (DP) and significantly fewer CD4⁺ CD8^- and CD4^- CD8⁺ SP thymocytes than wild-type controls