Analysis Tools
mortality/aging
|
• most affected mice die during the first week of life; of those surviving the first week, many die after weaning
|
liver/biliary system
|
• some homozygous mice exhibit enlargement of the liver
|
|
• by the second postnatal day, homozygous mutants can be identified by their pale orange color; the
orange pallor of their skin, nails and mucosa persists throughout life
|
growth/size/body
|
• homozygous mutant mice are much smaller than their littermates
|
|
• some homozygous mice exhibit enlargement of the liver
|
|
• the spleens of homozygous mice, while of normal size for about 3 days after birth, become hypertrophied and in adults are threefold heavier than those of unaffected mice
|
reproductive system
 |
• in the rare instance that a homozygous female becomes pregnant, she is likely to die giving birth
• in the rare instance that a homozygous female becomes pregnant, most of the pups are stillborn or die soon after birth
|
behavior/neurological
|
|
• in the rare instance that a homozygous female becomes pregnant, if the mother and any pups survive, the dam will abandon her offspring
|
digestive/alimentary system
|
• feces of mutant mice are orange colored and soft
|
hematopoietic system
anisocytosis
(
J:105409
)
microcytosis
(
J:105409
)
|
• in homozygous mice, the normal nodular splenic architecture is absent
|
|
• the spleens of homozygous mice, while of normal size for about 3 days after birth, become hypertrophied and in adults are threefold heavier than those of unaffected mice
|
immune system
|
• in homozygous mice, the normal nodular splenic architecture is absent
|
|
• the spleens of homozygous mice, while of normal size for about 3 days after birth, become hypertrophied and in adults are threefold heavier than those of unaffected mice
|
homeostasis/metabolism
|
• the circulating bilirubin level of affected mice is elevated, indicating red cell lysis
|
integument
|
• development of the hair coat occurs 4-5 days later in homozygotes than in their littermates
|
|
• by the second postnatal day, homozygous mutants can be identified by their pale orange color; the
orange pallor of their skin, nails and mucosa persists throughout life
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hereditary spherocytosis type 3 | DOID:0110918 |
OMIM:270970 |
J:157766 | |
