Phenotypes associated with this allele

• Allele Symbol: Tcrg^tm1Scar
• Allele Name: targeted mutation 1, Simon R Carding
• Allele ID: MGI:3615270
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcrg^tm1Scar/Tcrg^tm1Scar	B6.Cg-Tcrg^tm1Scar	MGI:3618691

Genotype
MGI:3618691

hm1

• Allelic Composition: Tcrg^tm1Scar/Tcrg^tm1Scar
• Genetic Background: B6.Cg-Tcrg^tm1Scar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell number ( J:105477 )

• increased numbers of TCR-gamma/delta T cells

increased macrophage cell number ( J:105477 )

• late in infection with Listeria monocytogenes

• at primary site of infection

• 3-4 fold increase in spleen

• 2 fold increase in peritoneal cavity

impaired granulocyte bactericidal activity ( J:105477 )

• no cytotoxic macrophage among splenocytes

abnormal immune system organ morphology ( J:105477 )

enlarged thymus ( J:105477 )

• after 6 weeks of age

thymus hyperplasia ( J:105477 )

• 1.5 fold increase in cellularity

enlarged spleen ( J:105477 )

• after 6 weeks of age

spleen hyperplasia ( J:105477 )

hematopoietic system

enlarged thymus ( J:105477 )

• after 6 weeks of age

thymus hyperplasia ( J:105477 )

• 1.5 fold increase in cellularity

enlarged spleen ( J:105477 )

• after 6 weeks of age

spleen hyperplasia ( J:105477 )

increased T cell number ( J:105477 )

• increased numbers of TCR-gamma/delta T cells

increased macrophage cell number ( J:105477 )

• late in infection with Listeria monocytogenes

• at primary site of infection

• 3-4 fold increase in spleen

• 2 fold increase in peritoneal cavity

impaired granulocyte bactericidal activity ( J:105477 )

• no cytotoxic macrophage among splenocytes

endocrine/exocrine glands

enlarged thymus ( J:105477 )

• after 6 weeks of age

thymus hyperplasia ( J:105477 )

• 1.5 fold increase in cellularity

growth/size/body

enlarged spleen ( J:105477 )

• after 6 weeks of age

spleen hyperplasia ( J:105477 )