Phenotypes associated with this allele

• Allele Symbol: Rab3b^tm1Sud
• Allele Name: targeted mutation 1, Thomas C Sudhof
• Allele ID: MGI:3615355
• Summary: 12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab3b^tm1Sud/Rab3b^tm1Sud	involves: 129P2/OlaHsd	MGI:3625935
cx2	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud	involves: 129 * 129P2/OlaHsd	MGI:3625933
cx3	Rab3a^tm1Sud/Rab3a^+ Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625945
cx4	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625947
cx5	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^+ Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625948
cx6	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^+ Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625949
cx7	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^+	involves: 129 * 129P2/OlaHsd	MGI:3625950
cx8	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625951
cx9	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud	involves: 129 * 129P2/OlaHsd	MGI:3625955
cx10	Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud	involves: 129P2/OlaHsd	MGI:3625938
cx11	Rab3b^tm1Sud/Rab3b^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129P2/OlaHsd	MGI:3625942
cx12	Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129P2/OlaHsd	MGI:3625944

Genotype
MGI:3625935

hm1

• Allelic Composition: Rab3b^tm1Sud/Rab3b^tm1Sud
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:105478 )

• mice are viable with no apparent decrease in weight or fertility

Genotype
MGI:3625933

cx2

• Allelic Composition: Rab3a^tm1Sud/Rab3a^tm1Sud; Rab3b^tm1Sud/Rab3b^tm1Sud
• Genetic Background: involves: 129 * 129P2/OlaHsd

normal phenotype

no abnormal phenotype detected ( J:105478 )

Genotype
MGI:3625945

cx3

• Allelic Composition: Rab3a^tm1Sud/Rab3a⁺; Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3c^tm1Sud/Rab3c^tm1Sud; Rab3d^tm1Rja/Rab3d^tm1Rja
• Genetic Background: involves: 129 * 129P2/OlaHsd

normal phenotype

no abnormal phenotype detected ( J:105478 )

Genotype
MGI:3625947

cx4

• Allelic Composition: Rab3a^tm1Sud/Rab3a^tm1Sud; Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3d^tm1Rja/Rab3d^tm1Rja
• Genetic Background: involves: 129 * 129P2/OlaHsd

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological

abnormal behavior ( J:105478 )

• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)

respiratory system

respiratory distress ( J:105478 )

• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts

Genotype
MGI:3625948

cx5

• Allelic Composition: Rab3a^tm1Sud/Rab3a^tm1Sud; Rab3b^tm1Sud/Rab3b⁺; Rab3c^tm1Sud/Rab3c^tm1Sud; Rab3d^tm1Rja/Rab3d^tm1Rja
• Genetic Background: involves: 129 * 129P2/OlaHsd

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• 50% of triple Rab3 knockouts with one copy of Rab3c survive

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age

respiratory system

respiratory distress ( J:105478 )

• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts

Genotype
MGI:3625949

cx6

• Allelic Composition: Rab3a^tm1Sud/Rab3a^tm1Sud; Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3c^tm1Sud/Rab3c⁺; Rab3d^tm1Rja/Rab3d^tm1Rja
• Genetic Background: involves: 129 * 129P2/OlaHsd

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• 50% of triple Rab3 knockouts that are heterozygous for Rab3c survive

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3c display a weight decrease at 5 weeks of age

Genotype
MGI:3625950

cx7

• Allelic Composition: Rab3a^tm1Sud/Rab3a^tm1Sud; Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3c^tm1Sud/Rab3c^tm1Sud; Rab3d^tm1Rja/Rab3d⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd

mortality/aging

neonatal lethality ( J:105478 )

Genotype
MGI:3625951

cx8

• Allelic Composition: Rab3a^tm1Sud/Rab3a^tm1Sud; Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3c^tm1Sud/Rab3c^tm1Sud; Rab3d^tm1Rja/Rab3d^tm1Rja
• Genetic Background: involves: 129 * 129P2/OlaHsd

mortality/aging

neonatal lethality, complete penetrance ( J:105478 )

• quadruple knockouts are born alive and react to stimuli; pups do not have milk in their stomachs and die soon after birth due to respiratory distress

homeostasis/metabolism

cyanosis ( J:105478 )

• newborn mice are cyanotic

nervous system

abnormal CNS synaptic transmission ( J:104983 )

• synaptic response (release) in presence of high calcium is potentiated in knockout neurons compared to control

abnormal excitatory postsynaptic currents ( J:104983 , J:105478 )

• repetitive stimulation of cultured quadruple knockout neurons induces strong initial facilitation; after ~5 synaptic responses, converged to similar amplitudes with controls (J:104983)

• EPSCs recover faster in mutant neurons than in control after depletion of the pool of synaptic vesicles (J:104983)

• EPSCs induced by action potentials are 30% smaller than in control (Rab3b,c,d triple knockout) animals; Rab3a deficient mice show no decline in EPSC indicating that lack of this isoform is not the sole reason for the decrease observed in quadruple knockouts (J:105478)

decreased neurotransmitter release ( J:105478 )

• in neurons, the synaptic release probability of vesicles is reduced by 40% compared to control triple knockout neurons; Rab3a-deficient neurons displayed no difference in release probability from wild-type

enhanced paired-pulse facilitation ( J:104983 )

• neurons show strong paired-pulse facilitation

respiratory system

abnormal breathing pattern ( J:105478 )

• newborn mice exhibit shallow and irregular breathing patterns

respiratory distress ( J:105478 )

• newborn mice exhibit respiratory distress and die soon after birth; if mice are placed in a high oxygen atmosphere, survival time is increased

Genotype
MGI:3625955

cx9

• Allelic Composition: Rab3a^tm1Sud/Rab3a^tm1Sud; Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3c^tm1Sud/Rab3c^tm1Sud
• Genetic Background: involves: 129 * 129P2/OlaHsd

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• only 50% of triple Rab3 knockouts with wild-type Rab3d survive

growth/size/body

decreased body weight ( J:105478 )

• male triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological

abnormal behavior ( J:105478 )

• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)

Genotype
MGI:3625938

cx10

• Allelic Composition: Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3c^tm1Sud/Rab3c^tm1Sud
• Genetic Background: involves: 129P2/OlaHsd

normal phenotype

no abnormal phenotype detected ( J:105478 )

Genotype
MGI:3625942

cx11

• Allelic Composition: Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3d^tm1Rja/Rab3d^tm1Rja
• Genetic Background: involves: 129P2/OlaHsd

normal phenotype

no abnormal phenotype detected ( J:105478 )

Genotype
MGI:3625944

cx12

• Allelic Composition: Rab3b^tm1Sud/Rab3b^tm1Sud; Rab3c^tm1Sud/Rab3c^tm1Sud; Rab3d^tm1Rja/Rab3d^tm1Rja
• Genetic Background: involves: 129P2/OlaHsd

normal phenotype

no abnormal phenotype detected ( J:105478 )

• triple knockouts are fully viable; mating and growth defects seen in other triple knockouts are rescued by presence of wild-type Rab3a allele