About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rab3ctm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:3615356
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rab3ctm1Sud/Rab3ctm1Sud involves: 129P2/OlaHsd MGI:3625936
cx2
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
involves: 129 * 129P2/OlaHsd MGI:3625940
cx3
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625965
cx4
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625951
cx5
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
involves: 129 * 129P2/OlaHsd MGI:3625955
cx6
Rab3atm1Sud/Rab3a+
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625945
cx7
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3b+
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625948
cx8
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3c+
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625949
cx9
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3d+
involves: 129 * 129P2/OlaHsd MGI:3625950
cx10
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129P2/OlaHsd MGI:3625944
cx11
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
involves: 129P2/OlaHsd MGI:3625938


Genotype
MGI:3625936
hm1
Allelic
Composition
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile




Genotype
MGI:3625940
cx2
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• double knockouts do not take care of offspring well




Genotype
MGI:3625965
cx3
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 100% of triple knockouts survive

growth/size/body
• male and female triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological
• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)




Genotype
MGI:3625951
cx4
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• quadruple knockouts are born alive and react to stimuli; pups do not have milk in their stomachs and die soon after birth due to respiratory distress

homeostasis/metabolism
• newborn mice are cyanotic

nervous system
• synaptic response (release) in presence of high calcium is potentiated in knockout neurons compared to control
• repetitive stimulation of cultured quadruple knockout neurons induces strong initial facilitation; after ~5 synaptic responses, converged to similar amplitudes with controls (J:104983)
• EPSCs recover faster in mutant neurons than in control after depletion of the pool of synaptic vesicles (J:104983)
• EPSCs induced by action potentials are 30% smaller than in control (Rab3b,c,d triple knockout) animals; Rab3a deficient mice show no decline in EPSC indicating that lack of this isoform is not the sole reason for the decrease observed in quadruple knockouts (J:105478)
• in neurons, the synaptic release probability of vesicles is reduced by 40% compared to control triple knockout neurons; Rab3a-deficient neurons displayed no difference in release probability from wild-type
• neurons show strong paired-pulse facilitation

respiratory system
• newborn mice exhibit shallow and irregular breathing patterns
• newborn mice exhibit respiratory distress and die soon after birth; if mice are placed in a high oxygen atmosphere, survival time is increased




Genotype
MGI:3625955
cx5
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 50% of triple Rab3 knockouts with wild-type Rab3d survive

growth/size/body
• male triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological
• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)




Genotype
MGI:3625945
cx6
Allelic
Composition
Rab3atm1Sud/Rab3a+
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3625948
cx7
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3b+
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of triple Rab3 knockouts with one copy of Rab3c survive

growth/size/body
• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age

respiratory system
• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts




Genotype
MGI:3625949
cx8
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3c+
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of triple Rab3 knockouts that are heterozygous for Rab3c survive

growth/size/body
• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3c display a weight decrease at 5 weeks of age




Genotype
MGI:3625950
cx9
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3d+
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3625944
cx10
Allelic
Composition
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• triple knockouts are fully viable; mating and growth defects seen in other triple knockouts are rescued by presence of wild-type Rab3a allele




Genotype
MGI:3625938
cx11
Allelic
Composition
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory