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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• double knockouts do not take care of offspring well
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• less than 100% of triple knockouts survive
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• male and female triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age
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• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• quadruple knockouts are born alive and react to stimuli; pups do not have milk in their stomachs and die soon after birth due to respiratory distress
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• synaptic response (release) in presence of high calcium is potentiated in knockout neurons compared to control
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• repetitive stimulation of cultured quadruple knockout neurons induces strong initial facilitation; after ~5 synaptic responses, converged to similar amplitudes with controls
(J:104983)
• EPSCs recover faster in mutant neurons than in control after depletion of the pool of synaptic vesicles
(J:104983)
• EPSCs induced by action potentials are 30% smaller than in control (Rab3b,c,d triple knockout) animals; Rab3a deficient mice show no decline in EPSC indicating that lack of this isoform is not the sole reason for the decrease observed in quadruple knockouts
(J:105478)
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• in neurons, the synaptic release probability of vesicles is reduced by 40% compared to control triple knockout neurons; Rab3a-deficient neurons displayed no difference in release probability from wild-type
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• neurons show strong paired-pulse facilitation
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• newborn mice exhibit shallow and irregular breathing patterns
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• newborn mice exhibit respiratory distress and die soon after birth; if mice are placed in a high oxygen atmosphere, survival time is increased
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• only 50% of triple Rab3 knockouts with wild-type Rab3d survive
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• male triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age
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• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)
|
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 50% of triple Rab3 knockouts with one copy of Rab3c survive
|
• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age
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• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts
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|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 50% of triple Rab3 knockouts that are heterozygous for Rab3c survive
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• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3c display a weight decrease at 5 weeks of age
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• triple knockouts are fully viable; mating and growth defects seen in other triple knockouts are rescued by presence of wild-type Rab3a allele
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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