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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rab3ctm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:3615356
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rab3ctm1Sud/Rab3ctm1Sud involves: 129P2/OlaHsd MGI:3625936
cx2
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
involves: 129 * 129P2/OlaHsd MGI:3625940
cx3
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625965
cx4
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625951
cx5
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
involves: 129 * 129P2/OlaHsd MGI:3625955
cx6
Rab3atm1Sud/Rab3a+
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625945
cx7
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3b+
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625948
cx8
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3c+
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129 * 129P2/OlaHsd MGI:3625949
cx9
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3d+
involves: 129 * 129P2/OlaHsd MGI:3625950
cx10
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
involves: 129P2/OlaHsd MGI:3625944
cx11
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
involves: 129P2/OlaHsd MGI:3625938


Genotype
MGI:3625936
hm1
Allelic
Composition
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile




Genotype
MGI:3625940
cx2
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• double knockouts do not take care of offspring well




Genotype
MGI:3625965
cx3
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 100% of triple knockouts survive

growth/size/body
• male and female triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological
• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)




Genotype
MGI:3625951
cx4
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• quadruple knockouts are born alive and react to stimuli; pups do not have milk in their stomachs and die soon after birth due to respiratory distress

homeostasis/metabolism
• newborn mice are cyanotic

nervous system
• synaptic response (release) in presence of high calcium is potentiated in knockout neurons compared to control
• repetitive stimulation of cultured quadruple knockout neurons induces strong initial facilitation; after ~5 synaptic responses, converged to similar amplitudes with controls (J:104983)
• EPSCs recover faster in mutant neurons than in control after depletion of the pool of synaptic vesicles (J:104983)
• EPSCs induced by action potentials are 30% smaller than in control (Rab3b,c,d triple knockout) animals; Rab3a deficient mice show no decline in EPSC indicating that lack of this isoform is not the sole reason for the decrease observed in quadruple knockouts (J:105478)
• in neurons, the synaptic release probability of vesicles is reduced by 40% compared to control triple knockout neurons; Rab3a-deficient neurons displayed no difference in release probability from wild-type
• neurons show strong paired-pulse facilitation

respiratory system
• newborn mice exhibit shallow and irregular breathing patterns
• newborn mice exhibit respiratory distress and die soon after birth; if mice are placed in a high oxygen atmosphere, survival time is increased




Genotype
MGI:3625955
cx5
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 50% of triple Rab3 knockouts with wild-type Rab3d survive

growth/size/body
• male triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological
• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)




Genotype
MGI:3625945
cx6
Allelic
Composition
Rab3atm1Sud/Rab3a+
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3625948
cx7
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3b+
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of triple Rab3 knockouts with one copy of Rab3c survive

growth/size/body
• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age

respiratory system
• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts




Genotype
MGI:3625949
cx8
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3c+
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of triple Rab3 knockouts that are heterozygous for Rab3c survive

growth/size/body
• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3c display a weight decrease at 5 weeks of age




Genotype
MGI:3625950
cx9
Allelic
Composition
Rab3atm1Sud/Rab3atm1Sud
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3d+
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3atm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3625944
cx10
Allelic
Composition
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Rab3dtm1Rja/Rab3dtm1Rja
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3dtm1Rja mutation (1 available); any Rab3d mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• triple knockouts are fully viable; mating and growth defects seen in other triple knockouts are rescued by presence of wild-type Rab3a allele




Genotype
MGI:3625938
cx11
Allelic
Composition
Rab3btm1Sud/Rab3btm1Sud
Rab3ctm1Sud/Rab3ctm1Sud
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3btm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3ctm1Sud mutation (1 available); any Rab3c mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory