Phenotypes associated with this allele

• Allele Symbol: Chrng^{tm1(Chrne)Mknn}
• Allele Name: targeted mutation 1, Michael Koenen
• Allele ID: MGI:3615397
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrng^tm1(Chrne)Mknn/Chrng^tm1(Chrne)Mknn	involves: 129/Sv * C57BL/6	MGI:3620131

Genotype
MGI:3620131

hm1

• Allelic Composition: Chrng^{tm1(Chrne)Mknn}/Chrng^{tm1(Chrne)Mknn}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal phrenic nerve morphology ( J:105142 )

• increased branching of the phrenic nerve is seen at P6 and at P70

abnormal phrenic nerve innervation pattern to diaphragm ( J:105142 )

• the pattern of innervation in the diaphragm is disordered and end-plates scattered over a wider territory with the half-maximum width of distribution increased about 2.2-fold

• however, the cellular and subcellular structure of nerve terminals is similar to wild-type

abnormal endplate potential ( J:105142 )

• only a single class of end-plate channels is present in the foot muscle at P2 and during the second postnatal week of life, in contrast to the 2 classes seen in wild-type mice

muscle

muscle phenotype ( J:105142 )

N • morphology of the soleus muscle is normal

behavior/neurological

behavior/neurological phenotype ( J:105142 )

N • no balance or locomotor coordination abnormalities are seen