Phenotypes associated with this allele

• Allele Symbol: Hoxd^{tm21(Hoxd11)Ddu}
• Allele Name: targeted mutation 21, Denis Duboule
• Allele ID: MGI:3616018
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd^tm21(Hoxd11)Ddu/Hoxd^tm21(Hoxd11)Ddu	involves: 129S2/SvPas	MGI:3616031
ht2	Hoxd^tm21(Hoxd11)Ddu/Hoxd^+	involves: 129S2/SvPas	MGI:3810764
ht3	Hoxd^tm21(Hoxd11)Ddu/Hoxd^+	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5508536
cx4	Dp(2Hoxd8-Hoxd9)2Ddu/Hoxd^tm21(Hoxd11)Ddu	involves: 129S2/SvPas	MGI:3810765

Genotype
MGI:3616031

hm1

• Allelic Composition: Hoxd^{tm21(Hoxd11)Ddu}/Hoxd^{tm21(Hoxd11)Ddu}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:131874 )

• 40% to 50% of mice die shortly after birth

renal/urinary system

renal/urinary system phenotype ( J:131874 )

N • mice have normal kidney size at birth and normal rates of apoptosis

polycystic kidney ( J:131874 )

• mice that survive at least one month develop unilateral or bilateral polycystic kidneys

abnormal renal tubule morphology ( J:131874 )

• tubules exhibit microcystic changes such as thin epithelial cells and the lumina is widened compared to in wild-type mice

dilated renal tubule ( J:131874 )

skeleton

cervical vertebral fusion ( J:70547 )

• atlas (C1) and axis (C2) completely fused

abnormal lumbar vertebrae morphology ( J:70547 )

• posteriorization of lumbo-sacral transition

growth/size/body

polycystic kidney ( J:131874 )

• mice that survive at least one month develop unilateral or bilateral polycystic kidneys

Genotype
MGI:3810764

ht2

• Allelic Composition: Hoxd^{tm21(Hoxd11)Ddu}/Hoxd⁺
• Genetic Background: involves: 129S2/SvPas

renal/urinary system

dilated renal tubule ( J:131874 )

• in 50% of mice

Genotype
MGI:5508536

ht3

• Allelic Composition: Hoxd^{tm21(Hoxd11)Ddu}/Hoxd⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

behavior/neurological

behavior/neurological phenotype ( J:199759 )

N • female mice exhibit normal courting behavior

Genotype
MGI:3810765

cx4

• Allelic Composition: Dp(2Hoxd8-Hoxd9)2Ddu/Hoxd^{tm21(Hoxd11)Ddu}
• Genetic Background: involves: 129S2/SvPas

renal/urinary system

renal/urinary system phenotype ( J:131874 )

N • unlike Del(2Hoxd1-Hoxd13)1Ddu heterozygotes, mice exhibit normal kidney morphology