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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		SordC57BL/Lia
sorbitol dehydogenase deficiency
MGI:3616090
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		SordC57BL/Lia/SordC57BL/Lia C57BL/LiA MGI:3616182
hm2
 		SordC57BL/Lia/SordC57BL/Lia involves: C57BL/LiA MGI:3836915
cx3
 		Gpx1tm1Ysh/Gpx1tm1Ysh
SordC57BL/Lia/SordC57BL/Lia 		involves: 129S1/Sv * 129X1/SvJ * C57BL/LiA MGI:3836917
cx4
 		Akr1b1tm1Skc/Akr1b1tm1Skc
SordC57BL/Lia/SordC57BL/Lia 		involves: 129S7/SvEvBrd * C57BL/LiA MGI:3836916
cx5
 		SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/0 		involves: C57BL * CBA MGI:3783853
cx6
 		SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)648Smch/0 		involves: C57BL * CBA MGI:3783858
cx7
 		SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)222Smch/0 		involves: C57BL * CBA MGI:3783861
cx8
 		SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch 		involves: C57BL * CBA MGI:3783852
cx9
 		SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch 		involves: C57BL * CBA MGI:3783848


Genotype
MGI:3616182
hm1
Allelic
Composition		 SordC57BL/Lia/SordC57BL/Lia
Genetic
Background		 C57BL/LiA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:44612 )
• homozygous mice exhibit no obvious abnormalities in the kidney or in other physiological functions




Genotype
MGI:3836915
hm2
Allelic
Composition		 SordC57BL/Lia/SordC57BL/Lia
Genetic
Background		 involves: C57BL/LiA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens morphology ( J:142446 )
• levels of sorbitol in the lens of 2 month old mice are very high (4.18 nmol/mg nmol/mg vs. 0.17 nmol/mg for wild-type)
cataract ( J:142446 )
• 5% of mice develop cataracts around 6 months of age
• 13 months after birth, rate of cataract incidence increases
• by 17 months of age, 69% of mice have cataracts

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cataract DOID:83 OMIM:601371
OMIM:PS116200
 J:142446




Genotype
MGI:3836917
cx3
Allelic
Composition		 Gpx1tm1Ysh/Gpx1tm1Ysh
SordC57BL/Lia/SordC57BL/Lia
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/LiA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1tm1Ysh mutation (2 available); any Gpx1 mutation (21 available)
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:142446 )
• cataract development is accelerated in these mice compared to mice homozygote null for just one locus
• 13% of mice have cataracts at 2 months of age, 16% of mice have cataracts at 3 months of age, and 26% of mice have cataracts at 4 months of age




Genotype
MGI:3836916
cx4
Allelic
Composition		 Akr1b1tm1Skc/Akr1b1tm1Skc
SordC57BL/Lia/SordC57BL/Lia
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/LiA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1b1tm1Skc mutation (0 available); any Akr1b1 mutation (27 available)
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:142446 )
N
• mice do not have the high incidence of cataracts that Sord homozygotes have




Genotype
MGI:3783853
cx5
Allelic
Composition		 SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/0
Genetic
Background		 involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:106642 )
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism
abnormal homeostasis ( J:106642 )
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Genotype
MGI:3783858
cx6
Allelic
Composition		 SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)648Smch/0
Genetic
Background		 involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal homeostasis ( J:106642 )
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

vision/eye
cataract ( J:106642 )
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts




Genotype
MGI:3783861
cx7
Allelic
Composition		 SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)222Smch/0
Genetic
Background		 involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal homeostasis ( J:106642 )
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Genotype
MGI:3783852
cx8
Allelic
Composition		 SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch
Genetic
Background		 involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:106642 )
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism
abnormal homeostasis ( J:106642 )
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Genotype
MGI:3783848
cx9
Allelic
Composition		 SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch
Genetic
Background		 involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:106642 )
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism
abnormal homeostasis ( J:106642 )
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory