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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mt1-Ptch1)MT22Mps
transgene insertion MT22, Matthew P Scott
MGI:3617013
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3617155
cx2
 		Hhiptm1Amc/Hhip+
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3617156
cx3
 		Hhiptm1Amc/Hhiptm1Amc
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3617157


Genotype
MGI:3617155
cx1
Allelic
Composition		 Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Mt1-Ptch1)MT22Mps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal diencephalon morphology ( J:94269 )
• look normal at E10.5 except for a slight overgrowth in the diencephalon
abnormal neuronal precursor cell number ( J:94269 )
• ventral neuronal precursor population 2X controls, other precursor populations normal

embryo




Genotype
MGI:3617156
cx2
Allelic
Composition		 Hhiptm1Amc/Hhip+
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhiptm1Amc mutation (1 available); any Hhip mutation (44 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Mt1-Ptch1)MT22Mps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:94269 )
• or exencephaly present
exencephaly ( J:94269 )
• or spina bifida present
abnormal neuronal precursor cell number ( J:94269 )
• ventral neuronal precursor population expanded considerably

craniofacial
small first pharyngeal arch ( J:94269 )
• hyperplastic first branchial arch

embryo
small first pharyngeal arch ( J:94269 )
• hyperplastic first branchial arch
spina bifida ( J:94269 )
• or exencephaly present




Genotype
MGI:3617157
cx3
Allelic
Composition		 Hhiptm1Amc/Hhiptm1Amc
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhiptm1Amc mutation (1 available); any Hhip mutation (44 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Mt1-Ptch1)MT22Mps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neural tube morphology ( J:94269 )
• ventral neuronal precursor population expanded and dorsal precursors decreased
enlarged floor plate ( J:94269 )
• 3X size of controls
incomplete rostral neuropore closure ( J:94269 )
• brain entirely open
abnormal neuronal precursor cell number ( J:94269 )
• entral neuronal precursor population expanded and dorsal precursors decreased

craniofacial
enlarged first pharyngeal arch ( J:94269 )
• first branchial arch considerably enlarged

vision/eye

embryo
enlarged first pharyngeal arch ( J:94269 )
• first branchial arch considerably enlarged
abnormal neural tube morphology ( J:94269 )
• ventral neuronal precursor population expanded and dorsal precursors decreased
enlarged floor plate ( J:94269 )
• 3X size of controls
incomplete rostral neuropore closure ( J:94269 )
• brain entirely open




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory