All Phenotypes Plp1<tm3Wst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plp1^tm3Wst
targeted mutation 3, Wilhelm Stoffel
MGI:3617313

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plp1^tm3Wst/Plp1^tm3Wst	B6.129S1-Plp1^tm3Wst	MGI:3620196

Allelic Composition	Plp1^tm3Wst/Plp1^tm3Wst
Genetic Background	B6.129S1-Plp1^tm3Wst

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plp1^tm3Wst mutation (0 available); any Plp1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelin sheath morphology ( J:105188 )

• myelin sheaths are compacted; however, myelin sheaths with remaining oligodendrocyte cytoplasm are detected

• a few degenerating myelin sheaths are seen on the optic nerve

abnormal optic nerve morphology ( J:105188 )

• a few degenerating myelin sheaths and degenerating nerve fibers are seen on the optic nerve

abnormal myelination ( J:105188 )

• redundant myelin is occasionally seen; however, small diameter axons are myelinated

vision/eye

abnormal optic nerve morphology ( J:105188 )

• a few degenerating myelin sheaths and degenerating nerve fibers are seen on the optic nerve

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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