Phenotypes associated with this allele

• Allele Symbol: Pkd1^tm2.1Ggg
• Allele Name: targeted mutation 2.1, Gregory G Germino
• Allele ID: MGI:3617325
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkd1^tm2.1Ggg/Pkd1^tm2.1Ggg	involves: 129S4/SvJae * Black Swiss * C57BL/6	MGI:3617390
ht2	Pkd1^tm1Ggg/Pkd1^tm2.1Ggg	involves: 129S4/SvJae * Black Swiss * C57BL/6	MGI:3617391

Genotype
MGI:3617390

hm1

• Allelic Composition: Pkd1^tm2.1Ggg/Pkd1^tm2.1Ggg
• Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:103719 )

• stage not specified, although embryos are recovered at E15.5

renal/urinary system

kidney cyst ( J:103719 )

endocrine/exocrine glands

pancreas cyst ( J:103719 )

homeostasis/metabolism

abnormal fluid regulation ( J:103719 )

• phenotype is stated to be similar to that of compound heterozygous Pkd1^tm1Ggg and Pkd1^tm2.1Ggg mice, however no data is presented in J:103719

cardiovascular system

hemorrhage ( J:103719 )

• phenotype is stated to be similar to that of compound heterozygous Pkd1^tm1Ggg and Pkd1^tm2.1Ggg mice, however no data is presented in J:103719

growth/size/body

pancreas cyst ( J:103719 )

kidney cyst ( J:103719 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic kidney disease 1		DOID:0110858	OMIM:173900	J:103719

Genotype
MGI:3617391

ht2

• Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2.1Ggg
• Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6

mortality/aging

prenatal lethality, complete penetrance ( J:103719 )

• stage not specified, although embryos are recovered at E14

homeostasis/metabolism

edema ( J:103719 )

• gross total body edema, seen at 14 dpc

polyhydramnios ( J:103719 )

cardiovascular system

hemorrhage ( J:103719 )

• seen at 14 dpc, examples include bleeding into the yolk sac cavity and cerebral hemorrhage