All Phenotypes Notch2<tm2Grid> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch2^tm2Grid
targeted mutation 2, Tom Gridley
MGI:3617327

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch2^tm2Grid/Notch2^tm2Grid	involves: 129S1/Sv * C57BL/6J	MGI:3617347
cn2	Notch2^tm2Grid/Notch2^tm3Grid Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * C57BL/6 * DBA	MGI:3778812

Allelic Composition	Notch2^tm2Grid/Notch2^tm2Grid
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm2Grid mutation (0 available); any Notch2 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:105278 )

• none survive beyond E11.5

growth/size/body

embryonic growth retardation ( J:105278 )

• at E10.5

cardiovascular system

pericardial edema ( J:105278 )

• at E10.5

abnormal cardiovascular system physiology ( J:105278 )

• cardiovascular dysfunction at E10.5

homeostasis/metabolism

pericardial edema ( J:105278 )

• at E10.5

embryo

embryonic growth retardation ( J:105278 )

• at E10.5

Allelic Composition	Notch2^tm2Grid/Notch2^tm3Grid Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm2Grid mutation (0 available); any Notch2 mutation (99 available)
Notch2^tm3Grid mutation (2 available); any Notch2 mutation (99 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal bile duct morphology ( J:133171 )

• by P7 few bile ducts are present

focal hepatic necrosis ( J:133171 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:133171 )

N	• blood urea nitrogen levels are normal

increased circulating bilirubin level ( J:133171 )

• in some mice

increased circulating alanine transaminase level ( J:133171 )

• in some mice

increased circulating alkaline phosphatase level ( J:133171 )

• in some mice

growth/size/body

decreased body size ( J:133171 )

decreased body weight ( J:133171 )

• at P8 to P9, mice are 19% lighter than wild-type

• at 4 to 5 weeks of age, mice are 15% lighter than wild-type

endocrine/exocrine glands

abnormal bile duct morphology ( J:133171 )

• by P7 few bile ducts are present

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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