All Phenotypes Dclk1<tm1.1Jgg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dclk1^tm1.1Jgg
targeted mutation 1.1, Joseph G Gleeson
MGI:3617379

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618306
ht2	Dclk1^tm1.1Jgg/Dclk1⁺	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618287
cx3	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Dcx^tm1Caw/Y	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618307
cx4	Dclk1^tm1.1Jgg/Dclk1⁺ Dcx^tm1Caw/Y	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618308
cx5	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Dcx^tm1Caw/Dcx^tm1Caw	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618309
cx6	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Dcx^tm1Caw/Dcx⁺	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618310
cx7	Dclk1^tm1.1Jgg/Dclk1⁺ Dcx^tm1Caw/Dcx^tm1Caw	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6	MGI:3618311

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1^tm1.1Jgg mutation (0 available); any Dclk1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:105300 )

• corpus callosum axonal projections are disrupted; decussation of interhemispheric corpus callosal axons is abnormal and axons fail to cross the midline

abnormal corpus callosum morphology ( J:105300 )

• Probst bundles are present in mutants

absent corpus callosum ( J:105300 )

• homozygous mice display an absence of the corpus callosum

absent hippocampal commissure ( J:105300 )

• hippocampal commissure is absent

cellular

abnormal axon guidance ( J:105300 )

• corpus callosum axonal projections are disrupted; decussation of interhemispheric corpus callosal axons is abnormal and axons fail to cross the midline

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1^tm1.1Jgg mutation (0 available); any Dclk1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal corpus callosum morphology ( J:105300 )

• alterations in corpus callosum thickness are observed in heterozygotes with the appearance of small Probst bundles

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Dcx^tm1Caw/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1^tm1.1Jgg mutation (0 available); any Dclk1 mutation (55 available)
Dcx^tm1Caw mutation (0 available); any Dcx mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:105300 )

• pups die before weaning, usually shortly after birth

nervous system

absent corpus callosum ( J:105300 )

• corpus callosum is absent

abnormal anterior commissure morphology ( J:105300 )

• anterior commissure is hypoplastic

abnormal stratification in cerebral cortex ( J:105300 )

• a cortical lamination defect, most notable in the lateral cortex is apparent

• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1⁺ Dcx^tm1Caw/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal corpus callosum morphology ( J:105300 )

• corpus callosum is hypoplastic

decreased anterior commissure size ( J:105300 )

• anterior commissure is severely reduced in thickness

abnormal neuron morphology ( J:105300 )

• cortical neuron distribution is altered, with neurons showing a much broader pattern of distribution

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Dcx^tm1Caw/Dcx^tm1Caw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:105300 )

• pups die before weaning, usually soon after birth

nervous system

abnormal brain commissure morphology ( J:105300 )

absent corpus callosum ( J:105300 )

• corpus callosum is absent

absent hippocampal commissure ( J:105300 )

absent anterior commissure ( J:105300 )

abnormal stratification in cerebral cortex ( J:105300 )

• there is no apparent laminar structure to the cortex

abnormal neuron morphology ( J:105300 )

• cortical neuron distribution is altered, showing a broader pattern of distribution

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Dcx^tm1Caw/Dcx⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent corpus callosum ( J:105300 )

• corpus callosum is absent

abnormal anterior commissure morphology ( J:105300 )

• anterior commissure is hypoplastic

abnormal stratification in cerebral cortex ( J:105300 )

• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3

Allelic Composition	Dclk1^tm1.1Jgg/Dclk1⁺ Dcx^tm1Caw/Dcx^tm1Caw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent corpus callosum ( J:105300 )

• corpus callosum is absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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