Analysis Tools
mortality/aging
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• 30% homozygous knock-in mice die before 4 months of age
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growth/size/body
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• body weigts are 15% less than wild-type controls, but number may be biased due to many of the smallest mice dying prior to the analysis
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behavior/neurological
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• mice are significantly more responsive to all sound intensities above background compared to wild-type
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• mice have a detectable postural intention tremor that worsens when mice are suspended by the tail
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• male mice display impaired coordination in the accelerating rotarod test compared to controls
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• surviving mice often exhibit hunched posture
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• mice show greater activity than wild-type over the first 20 minutes of a 60 minute period in a novel test environment
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• surviving mice are hypoactive
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• mice have an exaggerated response to human contact, including vigorous jumping and escape behavior
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