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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Snai1tm2Grid
targeted mutation 1, Tom Gridley
MGI:3617387
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid 		involves: 129S1/Sv * 129S4/SvJaeSor MGI:3715229
cn2
 		Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:3715232
cn3
 		Snai1tm1Grid/Snai1tm2Grid
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * C57BL/6 * CBA MGI:3715215
cn4
 		Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * C57BL/6 * CBA MGI:3715216


Genotype
MGI:3715229
cn1
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Snai1tm1Grid mutation (0 available); any Snai1 mutation (11 available)
Snai1tm2Grid mutation (1 available); any Snai1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:111702 )
• embryos survive as late as E9.5 when death occurs due to severe vascular defects

embryo
increased allantois apoptosis ( J:111702 )
• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5
abnormal direction of embryo turning ( J:111702 )
• at E9.5, 46% of mutant embryos show reversed axial rotation compared to no control embryos
abnormal allantois morphology ( J:111702 )
• at E8.5, poorly formed allantois with failure to fuse dorsally with the chorion is observed; there is a prominent dorsal bulge extruding dorsally. close to primitive streak

cardiovascular system
abnormal cardiac outflow tract development ( J:111702 )
• at E9.5, some mutant embryos display reversed position of the atrioventricular canal and outflow tract
abnormal heart development ( J:111702 )
• in 23% of embryos at E9.5, there is a vertical heart tube with ambiguous looping direction
abnormal fetal atrioventricular canal morphology ( J:111702 )
• at E9.5, in some embryos canal is reversed with outflow tract
abnormal direction of heart looping ( J:111702 )
• in 40% of mutant embryos, heart looping is reversed, whereas 37% show normal looping and remainder are ambiguous

cellular
increased allantois apoptosis ( J:111702 )
• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5




Genotype
MGI:3715232
cn2
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Snai1tm1Grid mutation (0 available); any Snai1 mutation (11 available)
Snai1tm2Grid mutation (1 available); any Snai1 mutation (11 available)
Snai2tm2Grid mutation (1 available); any Snai2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
open neural tube ( J:111702 )
• double mutants display an open neural tube at E9.5

growth/size/body
embryonic growth retardation ( J:111702 )

nervous system
nervous system phenotype ( J:111702 )
N
• in E8.5 cranial fold explants cultured for 48 hours, neural crest cell delamination and migration are observed, similar to control explants
open neural tube ( J:111702 )
• double mutants display an open neural tube at E9.5




Genotype
MGI:3715215
cn3
Allelic
Composition		 Snai1tm1Grid/Snai1tm2Grid
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Snai1tm1Grid mutation (0 available); any Snai1 mutation (11 available)
Snai1tm2Grid mutation (1 available); any Snai1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:121243 )
• animals are viable, fertile, and exhibit no phenotypic abnormalities




Genotype
MGI:3715216
cn4
Allelic
Composition		 Snai1tm1Grid/Snai1tm2Grid
Snai2tm2Grid/Snai2tm2Grid
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Snai1tm1Grid mutation (0 available); any Snai1 mutation (11 available)
Snai1tm2Grid mutation (1 available); any Snai1 mutation (11 available)
Snai2tm2Grid mutation (1 available); any Snai2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:121243 )
• resulting from cleft palate

craniofacial
abnormal Meckel's cartilage morphology ( J:121243 )
• the rostral portion of the Meckels cartilage is missing in neonates
frontal bone foramen ( J:121243 )
• enlarged frontal foramen in neonates
short parietal bone ( J:121243 )
• nenates have shortened parietal bones
short mandible ( J:121243 )
• mandible is shorter than in wild-type
domed cranium ( J:121243 )
• in neonates
abnormal palatal shelf morphology ( J:121243 )
• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5
cleft palate ( J:121243 )
• neonates show cleft palate
failure of palatal shelf elevation ( J:121243 )
• palatal shelves remain in a vertical growth orientation and fail to elevate

skeleton
abnormal Meckel's cartilage morphology ( J:121243 )
• the rostral portion of the Meckels cartilage is missing in neonates
frontal bone foramen ( J:121243 )
• enlarged frontal foramen in neonates
short parietal bone ( J:121243 )
• nenates have shortened parietal bones
short mandible ( J:121243 )
• mandible is shorter than in wild-type
domed cranium ( J:121243 )
• in neonates

digestive/alimentary system
abnormal palatal shelf morphology ( J:121243 )
• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5
cleft palate ( J:121243 )
• neonates show cleft palate
failure of palatal shelf elevation ( J:121243 )
• palatal shelves remain in a vertical growth orientation and fail to elevate

growth/size/body
abnormal palatal shelf morphology ( J:121243 )
• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5
cleft palate ( J:121243 )
• neonates show cleft palate
failure of palatal shelf elevation ( J:121243 )
• palatal shelves remain in a vertical growth orientation and fail to elevate




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory