Analysis Tools
mortality/aging
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• mice survived nolonger than 88 days
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reproductive system
 |
• spermatagonial cell death is abnormally high in 7 week old mice
|
 |
• no primary follicles are found in the periphery of the ovary
|
|
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• majority of oocytes appeared to be degenerating
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• significantly fewer germs cells in both males and females
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cellular
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• significantly fewer germs cells in both males and females
|
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• polyploid nuclei found in cells of kidney proximal tubules
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polyploidy
(
J:106084
)
|
• process of polyploidy is similar to the premature liver polyploidy of mice homozygous for Ercc1tm1Dwm
|
|
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• spermatagonial cell death is abnormally high in 7 week old mice
|
endocrine/exocrine glands
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• no primary follicles are found in the periphery of the ovary
|
|
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• majority of oocytes appeared to be degenerating
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renal/urinary system
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• mice died between 61 and 88 days
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homeostasis/metabolism
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• plasma lactate levels were 40% higher in 7-week-old mice compared to controls
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