Phenotypes associated with this allele

• Allele Symbol: Sostdc1^tm1Myan
• Allele Name: targeted mutation 1, Motoko Yanagita
• Allele ID: MGI:3617495
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sostdc1^tm1Myan/Sostdc1^tm1Myan	involves: 129X1/SvJ * C57BL/6J	MGI:3618157
cx2	Col4a3^tm1Dec/Col4a3^tm1Dec Sostdc1^tm1Myan/Sostdc1^tm1Myan	involves: 129X1/SvJ	MGI:4452039

Genotype
MGI:3618157

hm1

• Allelic Composition: Sostdc1^tm1Myan/Sostdc1^tm1Myan
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

fused molars ( J:105264 )

• mice exhibit fused teeth in the molar region

supernumerary teeth ( J:105264 )

• mutants exhibit supernumerary teeth in the incisors and molars

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:105264 )

• in response to cisplatin, 92% of homozygotes survive during the first 3 days whereas 54% of wild-type littermates die

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:105264 )

• in response to cisplatin, 92% of homozygotes survive during the first 3 days whereas 54% of wild-type littermates die

decreased physiological sensitivity to xenobiotic ( J:105264 )

• cisplatin-induced renal injuries such as renal proximal tubular damage and renal fibrosis are markedly reduced in mutants compared to wild-type on day 3

• tubular apoptosis is reduced in mutants in response to cisplatin administration

• induction of inflammatory markers including TNF-alpha, TGF-beta1 and IL-1beta is abolished in mutants in response to cisplatin administration, and infiltration of macrophages and monocytes in the kidney

• creatinine and blood urea nitrogen levels in the mutants are lower in mutants compared to wild-type 3 days after cisplatin administration

craniofacial

fused molars ( J:105264 )

• mice exhibit fused teeth in the molar region

supernumerary teeth ( J:105264 )

• mutants exhibit supernumerary teeth in the incisors and molars

renal/urinary system

decreased renal tubule apoptosis ( J:105264 )

• tubular apoptosis is reduced in mutants in response to cisplatin administration

cellular

decreased renal tubule apoptosis ( J:105264 )

• tubular apoptosis is reduced in mutants in response to cisplatin administration

growth/size/body

fused molars ( J:105264 )

• mice exhibit fused teeth in the molar region

supernumerary teeth ( J:105264 )

• mutants exhibit supernumerary teeth in the incisors and molars

Genotype
MGI:4452039

cx2

• Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec; Sostdc1^tm1Myan/Sostdc1^tm1Myan
• Genetic Background: involves: 129X1/SvJ

Sostdc1^tm1Myan/Sostdc1^tm1Myan Col4a3^tm1Dec/Col4a3^tm1Dec mice show less glomerular and tubular injury than Col4a3^tm1Dec/Col4a3^tm1Dec mice

mortality/aging

extended life span ( J:158731 )

• improved survival relative to Col4a3^tm1Dec single homozygotes beyond 13 weeks of age

renal/urinary system

albuminuria ( J:158731 )

• at 6 weeks of age have less severe albuminuria than in Col4a3^tm1Dec single homozygotes

glomerulonephritis ( J:158731 )

• severity is less than in Col4a3^tm1Dec single homozygotes

glomerulosclerosis ( J:158731 )

• at 10 weeks of age mice demonstrate glomerulosclerosis associated with inflammatory cell infiltration, interstitial fibrosis, tubular atrophy, and cast formation severity is less than in Col4a3^tm1Dec single homozygotes

renal interstitial fibrosis ( J:158731 )

• at 10 weeks of age mice demonstrate interstitial fibrosis that is less severe than in Col4a3^tm1Dec single homozygotes

renal tubule atrophy ( J:158731 )

• at 10 weeks of age mice demonstrate tubular atrophy that is less than in Col4a3^tm1Dec single homozygotes

renal cast ( J:158731 )

• at 10 weeks of age mice demonstrate cast formation that is less severe than in Col4a3^tm1Dec single homozygotes

immune system

glomerulonephritis ( J:158731 )

• severity is less than in Col4a3^tm1Dec single homozygotes

homeostasis/metabolism

increased circulating creatinine level ( J:158731 )

• at 10 weeks of age creatinine level is lower than in Col4a3^tm1Dec single homozygotes

increased blood urea nitrogen level ( J:158731 )

• at 10 weeks of age BUN is lower than in Col4a3^tm1Dec single homozygotes

albuminuria ( J:158731 )

• at 6 weeks of age have less severe albuminuria than in Col4a3^tm1Dec single homozygotes

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:158731 )

• compared to Col4a3^tm1Dec single homozygotes at 5 weeks of age