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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plin2tm1Chan
targeted mutation 1, Lawrence Chan
MGI:3617784
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plin2tm1Chan/Plin2tm1Chan B6.129-Plin2tm1Chan MGI:3618185


Genotype
MGI:3618185
hm1
Allelic
Composition
Plin2tm1Chan/Plin2tm1Chan
Genetic
Background
B6.129-Plin2tm1Chan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plin2tm1Chan mutation (0 available); any Plin2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
N
• normal differentiation of adipocytes and adipogenesis

homeostasis/metabolism
N
• lipolysis normal (J:105572)
• thin layer chromatography revealed no qualitative or quantitative changes in epidermal lipids relative to control mice (J:202513)
• 57% reduction in triglycerides although triglycderides are increased in the microsomal fraction of cells

liver/biliary system
• 57% reduction in triglycerides although triglycderides are increased in the microsomal fraction of cells
• on a normal diet, liver has lower lipid content
• on a fatty diet, density and size of lipid drops is less than in similarly fed controls although lipid levels are higher than on a normal diet

endocrine/exocrine glands
• the mean area of sebaceous glands is significantly reduced to approximately half the size of control glands
• however, no changes in sebaceous gland morphology or gland number are observed
• sebaceous glands contain significantly less cells than control glands
• fat content of milk is reduced about 12% from levels seen in controls
• sebaceous glands show a significant reduction in the number of proliferating cells relative to control glands, as determined by Ki67 staining

integument
• the mean area of sebaceous glands is significantly reduced to approximately half the size of control glands
• however, no changes in sebaceous gland morphology or gland number are observed
• sebaceous glands contain significantly less cells than control glands
• fat content of milk is reduced about 12% from levels seen in controls
• sebaceous glands show a significant reduction in the number of proliferating cells relative to control glands, as determined by Ki67 staining





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory