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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pthlhtm1.1Ack
targeted mutation 1.1, Andrew C Karaplis
MGI:3617812
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pthlhtm1Ack/Pthlhtm1.1Ack
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB/N MGI:3617821


Genotype
MGI:3617821
cn1
Allelic
Composition		 Pthlhtm1Ack/Pthlhtm1.1Ack
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1.1Ack mutation (0 available); any Pthlh mutation (19 available)
Pthlhtm1Ack mutation (0 available); any Pthlh mutation (19 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:69396 )
• phenotype is stated to be identical to that of conditional mutants with a Pthlhtm1Hmk allele in place of the Pthlhtm1.1Ack allele; however no data is presented in J:69396

skeleton

respiratory system

growth/size/body
protruding tongue ( J:69396 )
• shortening of the mandible results in protrusion of the tongue
small thoracic cavity ( J:69396 )
• narrow thorax
distended abdomen ( J:69396 )

craniofacial
protruding tongue ( J:69396 )
• shortening of the mandible results in protrusion of the tongue

digestive/alimentary system
protruding tongue ( J:69396 )
• shortening of the mandible results in protrusion of the tongue




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory