Phenotypes associated with this allele

• Allele Symbol: Cpt1b^tm1You
• Allele Name: targeted mutation 1, Yun You
• Allele ID: MGI:3617815
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpt1b^tm1You/Cpt1b^tm1You	involves: 129X1/SvJ * C57BL/6J	MGI:3715235
ht2	Cpt1b^tm1You/Cpt1b^+	involves: 129X1/SvJ * C57BL/6J	MGI:4421419

Genotype
MGI:3715235

hm1

• Allelic Composition: Cpt1b^tm1You/Cpt1b^tm1You
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:131341 )

• no homozygous embryos are found at E9.5-11.5

Genotype
MGI:4421419

ht2

• Allelic Composition: Cpt1b^tm1You/Cpt1b⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:131341 )

N • normal fasting blood glucose concentration

impaired adaptive thermogenesis ( J:131341 )

• 7% of heterozygous mice (n = 30) developed fatal hypothermia following a 3 h cold challenge, while none of the control mice (n = 30) were affected

• with a prolonged cold challenge (6 h), significantly more heterozygous mice developed fatal hypothermia (52% heterozygous mice vs. 21% control mice)

• with a prolonged cold challenge (6 h), an increased frequency of fatal hypothermia in females of both genotypes (67% female vs. 38% male heterozygous mice, and 33% female vs. 8% male control mice) is observed