Phenotypes associated with this allele

• Allele Symbol: E2f6^tm1Sgau
• Allele Name: targeted mutation 1, Stefan Gaubatz
• Allele ID: MGI:3617817
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	E2f6^tm1Sgau/E2f6^tm1Sgau	involves: 129S4/SvJae * C57BL/6	MGI:3618144
ht2	E2f6^tm1Sgau/E2f6^+	involves: 129S4/SvJae * C57BL/6	MGI:3618161

Genotype
MGI:3618144

hm1

• Allelic Composition: E2f6^tm1Sgau/E2f6^tm1Sgau
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:106219 )

♂ • few mature spematocytes are found in the testes and the epididymis is not completely filled with spermatocytes; however, males are fertile

increased Leydig cell number ( J:106219 )

♂

skeleton

thoracic vertebral transformation ( J:106219 )

• the 13th thoracic vertebra is transformed to the 1st lumbar vertebra in 25% of mice; in some cases transformation has incomplete penetrance or is asymmetrical

lumbar vertebral transformation ( J:106219 )

• the 6th lumbar vertebra is transformed to the 1st sacral vertebra in 75% of mice; in some cases transformation has incomplete penetrance or is asymmetrical

cellular

cellular phenotype ( J:106219 )

N • MEFs display normal proliferation and senescence

oligozoospermia ( J:106219 )

♂ • few mature spematocytes are found in the testes and the epididymis is not completely filled with spermatocytes; however, males are fertile

endocrine/exocrine glands

increased Leydig cell number ( J:106219 )

♂

Genotype
MGI:3618161

ht2

• Allelic Composition: E2f6^tm1Sgau/E2f6⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

skeleton

lumbar vertebral transformation ( J:106219 )

• the 6th lumbar vertebra is transformed to the 1st sacral vertebra in 40% of heterozygotes