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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
E2f6tm1Sgau
targeted mutation 1, Stefan Gaubatz
MGI:3617817
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
E2f6tm1Sgau/E2f6tm1Sgau involves: 129S4/SvJae * C57BL/6 MGI:3618144
ht2
E2f6tm1Sgau/E2f6+ involves: 129S4/SvJae * C57BL/6 MGI:3618161


Genotype
MGI:3618144
hm1
Allelic
Composition
E2f6tm1Sgau/E2f6tm1Sgau
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f6tm1Sgau mutation (0 available); any E2f6 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• few mature spematocytes are found in the testes and the epididymis is not completely filled with spermatocytes; however, males are fertile

skeleton
• the 13th thoracic vertebra is transformed to the 1st lumbar vertebra in 25% of mice; in some cases transformation has incomplete penetrance or is asymmetrical
• the 6th lumbar vertebra is transformed to the 1st sacral vertebra in 75% of mice; in some cases transformation has incomplete penetrance or is asymmetrical

cellular
N
• MEFs display normal proliferation and senescence
• few mature spematocytes are found in the testes and the epididymis is not completely filled with spermatocytes; however, males are fertile

endocrine/exocrine glands




Genotype
MGI:3618161
ht2
Allelic
Composition
E2f6tm1Sgau/E2f6+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f6tm1Sgau mutation (0 available); any E2f6 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the 6th lumbar vertebra is transformed to the 1st sacral vertebra in 40% of heterozygotes





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory